Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation
(6 available);
any
Cblb mutation
(56 available)
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immune system
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• in response to loading with CFSE followed by stimulation with anti-CD3
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hematopoietic system
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• in response to loading with CFSE followed by stimulation with anti-CD3
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cellular
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• in response to loading with CFSE followed by stimulation with anti-CD3
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation
(6 available);
any
Cblb mutation
(56 available)
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immune system
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• greatly decreased rate of immunoglobulin receptor internalization
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• greatly enhanced levels produced by mast cells upon stimulation
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• greatly enhanced levels produced by mast cells upon stimulation
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hematopoietic system
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• greatly decreased rate of immunoglobulin receptor internalization
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immune system
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N |
• T cell proliferation in response to loading with CFSE followed by stimulation with anti-CD3 is similar to controls, unlike in either single null mouse
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• similar to mice homozygous null for Itk alone, most T cells have an activated/memory like phenotype
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• partial rescue of defect in Th2 polarization compared to mice homozygous null for Itk alone
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• decrease in T cell numbers similar to that in mice homozygous null for Itk alone
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• partial rescue of decreased IL2 secretion in response to anti-CD3 anti-CD28 costimulation compared to mice homozygous null for Itk alone
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hematopoietic system
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• similar to mice homozygous null for Itk alone, most T cells have an activated/memory like phenotype
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• partial rescue of defect in Th2 polarization compared to mice homozygous null for Itk alone
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• decrease in T cell numbers similar to that in mice homozygous null for Itk alone
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immune system
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• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs/Vav1tm1Tyb double null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells
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hematopoietic system
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• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs/Vav1tm1Tyb double null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells
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immune system
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• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells
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hematopoietic system
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• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells
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Analysis Tools