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Targeted Allele Detail
Symbol: Atf4tm1Jml
Name: activating transcription factor 4; targeted mutation 1, Jeffrey M Leiden
MGI ID: MGI:2180371
Synonyms: CREB-2-
Gene: Atf4  Location: Chr15:80255184-80257541 bp, + strand  Genetic Position: Chr15, 37.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:62578
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region was replaced with a targeting construct containing a neomycin gene under the control of a PGK promoter. Northern blot analysis using a probe specific to exon 3 showed a lack of message in homozygous mutant mice, while Western blot analysis did not detect protein expression. (J:62578)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf4 Mutation:  15 strains or lines available
Original:  J:62578 Hettmann T, et al., Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol. 2000 Jun 1;222(1):110-23
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory