Atf4tm1Jml
Targeted Allele Detail
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Symbol: |
Atf4tm1Jml |
Name: |
activating transcription factor 4; targeted mutation 1, Jeffrey M Leiden |
MGI ID: |
MGI:2180371 |
Synonyms: |
CREB-2- |
Gene: |
Atf4 Location: Chr15:80139385-80141742 bp, + strand Genetic Position: Chr15, 37.85 cM
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Alliance: |
Atf4tm1Jml page
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Germline Transmission: |
Earliest citation of germline transmission:
J:62578
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The entire coding region was replaced with a targeting construct containing a neomycin gene under the control of a PGK promoter. Northern blot analysis using a probe specific to exon 3 showed a lack of message in homozygous mutant mice, while Western blot analysis did not detect protein expression.
(J:62578)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Atf4 Mutation: |
21 strains or lines available
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Original: |
J:62578 Hettmann T, et al., Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol. 2000 Jun 1;222(1):110-23 |
All: |
12 reference(s) |
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