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Targeted Allele Detail
Symbol: Fyntm1Rmp
Name: Fyn proto-oncogene; targeted mutation 1, Roger M Perlmutter
MGI ID: MGI:2179145
Synonyms: fynT, p59fyn, p59fynT
Gene: Fyn  Location: Chr10:39368855-39565381 bp, + strand  Genetic Position: Chr10, 20.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:70886
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo-derived cassette was used to replace exon 7b via homologous recombination, disrupting the thymic isoform of this gene while leaving the brain isoform intact. Western blot and immunoprecipitation did not detect protein product in thymocytes or splenocytes of homozygous mutant animals but protein product was present in brain. In Northern blot, mutant transcripts were detected in thymus whereas wild-type transcripts were detected in brain, proving successful knock out of the thymic isoform. (J:70886)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fyn Mutation:  24 strains or lines available
ES cell line = D3J8.
Original:  J:70886 Appleby MW, et al., Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell. 1992 Sep 4;70(5):751-63
All:  17 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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