Egfr^Wa5
Chemically induced Allele Detail

Summary

• Symbol: Egfr^Wa5
• Name: epidermal growth factor receptor; waved 5
• MGI ID: MGI:2178387
• Synonyms: Gena239, GENA 239
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^Wa5 page

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/cAnN
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Originally named Waved 5, this phenotypic mutant was deemed allelic to Egfr when it failed to complement Egfr^tm1Mag. The entire coding region of Egfr was subsequently sequenced. A single point mutation was found causing a GAT to GGT missense mutation in exon 21. This results in an aspartic acid to glycine change at amino acid residue 833 altering a DFG motif critical to the tyrosine kinase function of this gene. (J:75964, J:92308)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Egfr^Wa5

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 85 strains or lines available

Notes

This allele contains the same point mutation as in Egfr^Vel in a different ENU screen and strain. Both alleles are considered antimorphs.

References

• Original: J:75964 Thaung C, et al., Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet. 2002 Apr 1;11(7):755-67
• All: 23 reference(s)