Gria2^tm1.1Phs
Targeted Allele Detail

Summary

• Symbol: Gria2^tm1.1Phs
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1.1, Peter H Seeburg
• MGI ID: MGI:2178125
• Synonyms: GluR-B^R, Gria2^R
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm1.1Phs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50929
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: This heritable allele is a derivative of Gria2^tm1Phs in which the loxP flanked neomycin cassette was removed by crossing mice carrying this allele to mice carrying the Tg(CMV-Cre)1Cgn transgene. A single loxP site in intron 11 remained in place of the neomycin cassette. (J:50929)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 75 strains or lines available

References

• Original: J:50929 Kask K, et al., The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13777-82
• All: 17 reference(s)