Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm1.1Phs mutation
(2 available);
any
Gria2 mutation
(75 available)
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nervous system
N |
• AMPA receptor mediated currents in hippocampal CA1 pyramidal neurons display current-voltage relations identical to wild-type; reversal potential of inhibitory interneurons in dentate gyrus basket cells is the same as measured in wild-type cells
• no differences are detected in brain architecture
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation
(0 available);
any
Adarb1 mutation
(35 available)
Gria2tm1.1Phs mutation
(2 available);
any
Gria2 mutation
(75 available)
Tg(SLC18A3-cre)KMisa mutation
(2 available)
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behavior/neurological
N |
• mice exhibit normal motor function until 6 months of age
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nervous system
N |
• motor neuron death observed in Adarb1tm1.1Skwa/Adarb1tm1.1Skwa Tg(SLC18A3-cre)KMisa mice is prevented
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mortality/aging
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• compound mutant mice survive up to P35 (partial rescue; extended postnatal survival)
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normal phenotype
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• double homozygous null mice appear normal at all ages, as judged by food intake, weight increase, postnatal development, breeding and general behavior (full rescue)
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