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Tyrcm1OR
Spontaneous Allele Detail
Summary
Symbol: Tyrcm1OR
Name: tyrosinase; albino mottling 1, Oak Ridge
MGI ID: MGI:2153728
Synonyms: cm1OR, Tyrc-1R
Gene: Tyr  Location: Chr7:87073979-87142637 bp, - strand  Genetic Position: Chr7, 49.01 cM
Alliance: Tyrcm1OR page
Mutation
origin
Strain of Origin:  C3H/Rl
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Transposon insertion
 
Mutation detailsThe mutation is a 5.4kb intracisternal A particle (IAP) element insertion upstream of the promoter. This is a hypomorphic allele; Northern blot analysis and RT-PCR results show that expression is at much lower levels in homozygous than in wild-type mice. (J:38209)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  373 strains or lines available
References
Original:  J:38209 Wu M, et al., Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):890-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory