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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrcm1OR
albino mottling 1, Oak Ridge
MGI:2153728
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyrcm1OR/Tyrcm1OR involves: C3H/Rl MGI:4431036
ht2
 		Tyrcm1OR/Tyrc involves: C3H/Rl MGI:4431054
ht3
 		Tyrcm1OR/Tyrc-ch involves: C3H/Rl MGI:4431055


Genotype
MGI:4431036
hm1
Allelic
Composition		 Tyrcm1OR/Tyrcm1OR
Genetic
Background		 involves: C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrcm1OR mutation (1 available); any Tyr mutation (375 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:38209 )
• variegated white with interspersed dark hairs and agouti pigmentation
absent hair follicle melanin granules ( J:38209 )
• in unpigmented regions melanocytes are present
abnormal skin pigmentation ( J:38209 )
• EM analysis of skin from 4 day-old mice shows fewer pigmented follicles compared with skin of wild-type mice
• pattern of melanosome distribution is similar to that seen in wild-type control hair follicles
ocular albinism ( J:38209 )
• eyes are pink

vision/eye
ocular albinism ( J:38209 )
• eyes are pink

integument
abnormal coat/hair pigmentation ( J:38209 )
• variegated white with interspersed dark hairs and agouti pigmentation
absent hair follicle melanin granules ( J:38209 )
• in unpigmented regions melanocytes are present
abnormal skin pigmentation ( J:38209 )
• EM analysis of skin from 4 day-old mice shows fewer pigmented follicles compared with skin of wild-type mice
• pattern of melanosome distribution is similar to that seen in wild-type control hair follicles




Genotype
MGI:4431054
ht2
Allelic
Composition		 Tyrcm1OR/Tyrc
Genetic
Background		 involves: C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation (79 available); any Tyr mutation (375 available)
Tyrcm1OR mutation (1 available); any Tyr mutation (375 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
mottled coat ( J:38209 )
• areas of white and wild-type agouti fur

integument
mottled coat ( J:38209 )
• areas of white and wild-type agouti fur




Genotype
MGI:4431055
ht3
Allelic
Composition		 Tyrcm1OR/Tyrc-ch
Genetic
Background		 involves: C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-ch mutation (79 available); any Tyr mutation (375 available)
Tyrcm1OR mutation (1 available); any Tyr mutation (375 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
mottled coat ( J:38209 )
• areas of white and wild-type agouti fur

integument
mottled coat ( J:38209 )
• areas of white and wild-type agouti fur




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory