About   Help   FAQ
Thbs2tm1Bst
Targeted Allele Detail
Summary
Symbol: Thbs2tm1Bst
Name: thrombospondin 2; targeted mutation 1, Paul Bornstein
MGI ID: MGI:2153006
Synonyms: Thbs2-, Tsp-2-, TSP2-
Gene: Thbs2  Location: Chr17:14885762-14914497 bp, - strand  Genetic Position: Chr17, 8.95 cM, cytoband A3-B
Alliance: Thbs2tm1Bst page
Thbs2tm1Bst/Thbs2tm1Bst mice show increased flexibility of tail tendons and ligaments such that a knot can be tied in the tail

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45509
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 2.6kb genomic fragment containing exons 2 and 3. Northern blot analysis demonstrated that no transcript was produced from this allele and Western blot analysis revealed that the protein was not detectable in homozygous E17 embryos. (J:45509)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Thbs2 Mutation:  66 strains or lines available
Notes
ES cell line = J1 (129S4/SvJae) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).
References
Original:  J:45509 Kyriakides TR, et al., Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol. 1998 Jan 26;140(2):419-30
All:  53 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory