Phenotypes associated with this allele

• Allele Symbol: Thbs2^tm1Bst
• Allele Name: targeted mutation 1, Paul Bornstein
• Allele ID: MGI:2153006
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thbs2^tm1Bst/Thbs2^tm1Bst	either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)	MGI:3033214
cx2	Thbs1^tm1Hyn/Thbs1^tm1Hyn Thbs2^tm1Bst/Thbs2^tm1Bst	involves: 129T2/SvEms * 129X1/SvJ	MGI:3032867

Genotype
MGI:3033214

hm1

• Allelic Composition: Thbs2^tm1Bst/Thbs2^tm1Bst
• Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thbs2^tm1Bst/Thbs2^tm1Bst mice show increased flexibility of tail tendons and ligaments such that a knot can be tied in the tail

mortality/aging

premature death ( J:45509 )

• specific cause of death not determined

• higher incidence of sporadic death of adult mice

behavior/neurological

abnormal tail movements ( J:45509 )

• little control of tail movement

tail dragging ( J:45509 )

• when moving

cardiovascular system

abnormal blood vessel morphology ( J:45509 )

• increased density of small and medium blood vessels in many tissues

abnormal angiogenesis ( J:69756 )

• increased number and size of blood vessels associated with tumor vascularization

hemorrhage ( J:45509 )

• bleeding diathesis (tendency to bleed)

hematopoietic system

thrombocytosis ( J:45509 )

limbs/digits/tail

abnormal tail morphology ( J:45509 )

• tails could be tied in knots

• authors postulate due to abnormal tail tendon and intervertebral ligaments

muscle

abnormal tendon morphology ( J:45509 )

• lax

abnormal tendon collagen fibril morphology ( J:45509 )

• inceased diameter of collagen fibrils in tail tendons

skeleton

abnormal tendon morphology ( J:45509 )

• lax

abnormal tendon collagen fibril morphology ( J:45509 )

• inceased diameter of collagen fibrils in tail tendons

kyphosis ( J:45509 )

• incomplete penetrance

• with aging, appeared to be attributable to lax ligaments

increased bone mineral density ( J:45509 )

increased compact bone thickness ( J:45509 )

abnormal ligament morphology ( J:45509 )

• lax

homeostasis/metabolism

increased bleeding time ( J:45509 )

• prolonged bleeding time

increased incidence of tumors by chemical induction ( J:69756 )

• more rapid induction and increased numbers of epithelial papillomas by DMBA followed by PMA than in controls

• earlier progression to squamous cell carcinoma than in controls

enhanced wound healing ( J:58476 )

• more rapid healing than control animals after excisional (biopsy punch) wounds

integument

abnormal cutaneous collagen fibril morphology ( J:45509 )

• disoganized, widely spaced collagen fibers

• abnormal collagen fibrils, with uneven contours and larger than normal size

decreased skin tensile strength ( J:45509 )

• skin very fragile

cellular

decreased apoptosis ( J:69756 )

• decreased tumor cell apoptosis

neoplasm

increased incidence of tumors by chemical induction ( J:69756 )

• more rapid induction and increased numbers of epithelial papillomas by DMBA followed by PMA than in controls

• earlier progression to squamous cell carcinoma than in controls

Genotype
MGI:3032867

cx2

• Allelic Composition: Thbs1^tm1Hyn/Thbs1^tm1Hyn; Thbs2^tm1Bst/Thbs2^tm1Bst
• Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

mortality/aging

prenatal lethality, incomplete penetrance ( J:78876 )

• 1/2 the expected number of double homozygous mutant mice are born

immune system

impaired macrophage chemotaxis ( J:78876 )

• to wound site

lung inflammation ( J:78876 )

• acute and chronic

limbs/digits/tail

abnormal tail morphology ( J:78876 )

• ductile

respiratory system

lung inflammation ( J:78876 )

• acute and chronic

skeleton

lordosis ( J:78876 )

• mild

homeostasis/metabolism

increased bleeding time ( J:78876 )

• prolonged bleeding time

delayed wound healing ( J:78876 )

• prolonger persistence of inflammation and delayed scab loss at site of wound

integument

abnormal skin condition ( J:78876 )

• fragile

cellular

impaired macrophage chemotaxis ( J:78876 )

• to wound site

hematopoietic system

impaired macrophage chemotaxis ( J:78876 )

• to wound site