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Cdkn1ctm1Kat
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1ctm1Kat
Name: cyclin-dependent kinase inhibitor 1C (P57); targeted mutation 1, Katsuhiko Takahashi
MGI ID: MGI:1933758
Synonyms: p57-, p57Kip2(-)
Gene: Cdkn1c  Location: Chr7:143458350-143461050 bp, - strand  Genetic Position: Chr7, 88.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61190
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of the entire coding region, including exons 1, 2, 3 and part of exon 4 with a neomycin cassette. (J:61190)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1c Mutation:  7 strains or lines available
References
Original:  J:61190 Takahashi K, et al., Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation. J Biochem. 2000 Jan;127(1):73-83
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory