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En2tm2Alj
Targeted Allele Detail
Summary
Symbol: En2tm2Alj
Name: engrailed 2; targeted mutation 2, Alexandra L Joyner
MGI ID: MGI:1930810
Synonyms: En-2ntd
Gene: En2  Location: Chr5:28370692-28377164 bp, + strand  Genetic Position: Chr5, 13.94 cM
Alliance: En2tm2Alj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17203
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of 324 bp of exon 1, including the sequences encoding the 108 N-terminal amino acids, with a neomycin cassette. (J:17203)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any En2 Mutation:  104 strains or lines available
References
Original:  J:17203 Millen KJ, et al., Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development. 1994 Mar;120(3):695-706
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory