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Irf8tm1Hor
Targeted Allele Detail
Summary
Symbol: Irf8tm1Hor
Name: interferon regulatory factor 8; targeted mutation 1, Ivan Horak
MGI ID: MGI:1926332
Synonyms: ICSBP-, IRF-8-
Gene: Irf8  Location: Chr8:121463097-121483433 bp, + strand  Genetic Position: Chr8, 70.05 cM
Alliance: Irf8tm1Hor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36038
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin gene was inserted into the second exon, disrupting sequences encoding the DNA binding domain. (J:36038)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Irf8tm1Hor
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:  32 strains or lines available
References
Original:  J:36038 Holtschke T, et al., Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996 Oct 18;87(2):307-17
All:  107 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory