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Irf8tm1Hor
Targeted Allele Detail
Nomenclature
Symbol: Irf8tm1Hor
Name: interferon regulatory factor 8; targeted mutation 1, Ivan Horak
MGI ID: MGI:1926332
Synonyms: ICSBP-, IRF-8-
Gene: Irf8  Location: Chr8:120736358-120756694 bp, + strand  Genetic Position: Chr8, 70.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36038
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin gene was inserted into the second exon, disrupting sequences encoding the DNA binding domain. (J:36038)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:  6 strains or lines available
References
Original:  J:36038 Holtschke T, et al., Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996 Oct 18;87(2):307-17
All:  88 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory