Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8tm1Hor mutation
(1 available);
any
Irf8 mutation
(32 available)
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immune system
hematopoietic system
Allelic
Composition |
Irf8tm1Hor/Irf8tm1Hor
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Genetic
Background |
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8tm1Hor mutation
(1 available);
any
Irf8 mutation
(32 available)
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mortality/aging
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• 80% of mice infected with vacinia virus or lymphocytic choriomeningitis virus die within 10 to 20 days unlike wild-type mice that control the infection
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• 33% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis
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growth/size/body
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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• spleen weights of 500 to 2000 mg
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immune system
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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• spleen weights of 500 to 2000 mg
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• the relative frequency of B cells is decreased in the spleen
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• the relative frequency of T cells is decreased in the spleen
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• 38.9+/-9.5 leukocytes per ul x103 compared to 6.76+/-0.55 leukocytes per ul x103 in wild-type mice
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• the frequency of granulocytes in the spleen, lymph node, peripheral blood and bone marrow is increased relative to in wild-type mice
• the frequency of granulocytes in the spleen and lymph nodes increases with age
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• mice exhibit lymphocyte and plasma cells hyperplasia in Peyer's patches and the lamina propria
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• the frequency of B cells is increased in the lymph nodes
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• the relative frequency of B cells is decreased in the spleen
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• the frequency of macrophage in the spleen, lymph node and bone marrow is increased relative to in wild-type mice
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• the frequency of plasma cells I reduced in the bone marrow while mice exhibit plasma cells hyperplasia in Peyer's patches and the lamina propria
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• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
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• lymph nodes are enlarged 5-fold and are populated by neutrophilic granulocytes
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• interferon-gamma production following stimulation with ConA is reduced 3-fold while production following stimulation with LPS is decreased more than 100-fold compared to in wild-type mice
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• 80% of mice infected with vacinia virus or lymphocytic choriomeningitis virus die within 10 to 20 days unlike wild-type mice that control the infection
• cytotoxic T lymphocyte response is reduced 3- to 10-fold following infection with vesicular stomatitis virus and vacinia virus
• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
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neoplasm
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• all mice develop hematologic neoplasia resembling chronic myelogenous leukemia
• 33% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis
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hematopoietic system
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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• spleen weights of 500 to 2000 mg
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• erythropoiesis is increased compared to in wild-type mice
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• bone marrows exhibit hypercellularity due to an increase in mature granulocytes and their precursors compared to in wild-type mice
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• mice exhibit increased proliferation of abnormal megakaryocytes
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• the relative frequency of B cells is decreased in the spleen
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• the relative frequency of T cells is decreased in the spleen
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• 38.9+/-9.5 leukocytes per ul x103 compared to 6.76+/-0.55 leukocytes per ul x103 in wild-type mice
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• the frequency of granulocytes in the spleen, lymph node, peripheral blood and bone marrow is increased relative to in wild-type mice
• the frequency of granulocytes in the spleen and lymph nodes increases with age
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• mice exhibit lymphocyte and plasma cells hyperplasia in Peyer's patches and the lamina propria
|
|
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• the frequency of B cells is increased in the lymph nodes
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• the relative frequency of B cells is decreased in the spleen
|
|
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• the frequency of macrophage in the spleen, lymph node and bone marrow is increased relative to in wild-type mice
|
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• the frequency of plasma cells I reduced in the bone marrow while mice exhibit plasma cells hyperplasia in Peyer's patches and the lamina propria
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• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
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liver/biliary system
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8tm1Hor mutation
(1 available);
any
Irf8 mutation
(32 available)
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immune system
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• coupling antigen to anti-Clec9a antibody fails to enhance antibody response
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Allelic
Composition |
Irf8tm1Hor/Irf8+
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Genetic
Background |
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8tm1Hor mutation
(1 available);
any
Irf8 mutation
(32 available)
|
|
|
mortality/aging
|
|
• 9% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis
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neoplasm
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• hematological neoplasia
• 9% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis
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hematopoietic system
immune system
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• B cell development blocked in bone marrow at the pre-B cell stage
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• numbers of double negative dendritic cells reduced in spleen to half of control levels and very few found in thymus
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• plasmacytoid dendritic cells in spleen reduced considerably
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• peripheral B cells lacking
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• reduced numbers of both types of single positive T cells
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• display cytoplasmic mu heavy chain and high levels of preBCR
• pre-B cells held up is S and G2 phase of cell cycle
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• 5 fold increase in numbers
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hematopoietic system
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• B cell development blocked in bone marrow at the pre-B cell stage
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• numbers of double negative dendritic cells reduced in spleen to half of control levels and very few found in thymus
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• plasmacytoid dendritic cells in spleen reduced considerably
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• peripheral B cells lacking
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• reduced numbers of both types of single positive T cells
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• display cytoplasmic mu heavy chain and high levels of preBCR
• pre-B cells held up is S and G2 phase of cell cycle
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• 5 fold increase in numbers
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Gtbz mutation
(0 available);
any
Id2 mutation
(19 available)
Irf8tm1Hor mutation
(1 available);
any
Irf8 mutation
(32 available)
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hematopoietic system
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• in reconstitution assays, bone marrow cells are not able to generate CD8alpha+ dendritic cells
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Analysis Tools
