Aldh1a2tm1Ipc
Targeted Allele Detail
|
Symbol: |
Aldh1a2tm1Ipc |
Name: |
aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pierre Chambon |
MGI ID: |
MGI:1857891 |
Synonyms: |
Raldh2- |
Gene: |
Aldh1a2 Location: Chr9:71123071-71203525 bp, + strand Genetic Position: Chr9, 39.85 cM
|
Alliance: |
Aldh1a2tm1Ipc page
|
|
Abnormal development of laryngeal and tracheal cartilages in Aldh1a2tm1Dll/Aldh1a2tm1Ipc and Aldh1a2tm1Dll/Aldh1a2tm1Dll mice and absence of thymus and parathyroid glands in Aldh1a2tm1Dll/Aldh1a2tm1Ipc mice
Show the 3 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:54067
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutation: |
|
Insertion
|
|
|
Mutation details: A neomcycin selection cassette was inserted into the fourth exon of the gene at codon 140. This mutation is predicted to cause a premature truncation of the protein before the enzyme active site.
(J:54067)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Aldh1a2 Mutation: |
36 strains or lines available
|
|
Original: |
J:54067 Niederreither K, et al., Embryonic retinoic acid synthesis is essential for early mouse post-implantation development [see comments]. Nat Genet. 1999 Apr;21(4):444-8 |
All: |
44 reference(s) |
|