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Targeted Allele Detail
Symbol: Fcer1gtm1Rav
Name: Fc receptor, IgE, high affinity I, gamma polypeptide; targeted mutation 1, Jeffrey V Ravetch
MGI ID: MGI:1857165
Synonyms: Fcepsilonrgamma-, Fcer1gtm1, Fcer1gtm1Ra, Fcerg1tm1, FcgammaR-, FcR-, FcRg-, FcR gamma-, FcRgamma-, FcRgammac-, FcRgamma-chain-, FcRgammanl, FcRKO, gamma-
Gene: Fcer1g  Location: Chr1:171229572-171234365 bp, - strand  Genetic Position: Chr1, 79.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:39248
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was inserted into exon 2, creating a new stop codon 239 bp downstream of the integration site. RT-PCR analysis on RNA isolated from activated macrophages, mast cells and NK cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from activated macrophages, mast cells and NK cells of homozygous mice confirmed that no protein is encoded by this allele. (J:39248)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Fcer1g Mutation:  13 strains or lines available
Original:  J:39248 Takai T, et al., FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell. 1994 Feb 11;76(3):519-29
All:  274 reference(s)

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