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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcer1gtm1Rav
targeted mutation 1, Jeffrey V Ravetch
MGI:1857165
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcer1gtm1Rav/Fcer1gtm1Rav B6.129P2-Fcer1gtm1Rav MGI:4459639
hm2
 		Fcer1gtm1Rav/Fcer1gtm1Rav involves: 129P2/OlaHsd MGI:4830336
hm3
 		Fcer1gtm1Rav/Fcer1gtm1Rav involves: 129P2/OlaHsd * C57BL/6 MGI:2448612
cx4
 		Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1Lll/Tyrobptm1Lll 		involves: 129P2/OlaHsd MGI:3840591
cx5
 		C3tm1Crr/C3tm1Crr
Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3784426
cx6
 		Cd247tm1Lov/Cd247tm1Lov
Fcer1gtm1Rav/Fcer1gtm1Rav 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:2448651
cx7
 		Fcer1gtm1Rav/Fcer1gtm1Rav
Hexbtm1Rlp/Hexbtm1Rlp 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3579384
cx8
 		Cd247tm1Mhu/Cd247tm1Mhu
Fcer1gtm1Rav/Fcer1gtm1Rav 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3818419
cx9
 		Fcer1gtm1Rav/Fcer1gtm1Rav
Del(7Tyrobp-Hcst)1Ttk/Del(7Tyrobp-Hcst)1Ttk 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3840594
cx10
 		Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1.1Viv/Tyrobptm1.1Viv 		involves: 129P2/OlaHsd * C57BL/6 MGI:3818420
cx11
 		Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1Lll/Tyrobptm1Lll 		involves: 129P2/OlaHsd * C57BL/6 MGI:3818498
cx12
 		Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3784425


Genotype
MGI:4459639
hm1
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic
Background		 B6.129P2-Fcer1gtm1Rav
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:160680 )
• by BMDCs in response to water-soluble mannans from Serotype A C. albicans
• by BMDCs stimulated by yeast or hyphae forms of C.albicans
decreased interleukin-10 secretion ( J:160680 )
• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans
• by BMDCs stimulated by yeast or hyphae forms of C.albicans
decreased interleukin-12b secretion ( J:160680 )
• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans
• by BMDCs stimulated by yeast or hyphae forms of C.albicans
decreased interleukin-23 secretion ( J:160680 )
• by BMDCs stimulated by yeast form of C.albicans
decreased interleukin-6 secretion ( J:160680 )
• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans
• by BMDCs stimulated by yeast or hyphae forms of C.albicans
decreased tumor necrosis factor secretion ( J:160680 )
• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans
• by BMDCs stimulated by yeast or hyphae forms of C.albicans




Genotype
MGI:4830336
hm2
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:163761 )
• after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice
• however, transfer of bone marrow from KitW-sh homozygotes restores repletion

hematopoietic system
abnormal hemoglobin ( J:168556 )
• increased hemisphere hemoglobin content in mouse brains injected with phosphate buffered saline
decreased platelet aggregation ( J:165893 )
• mutants exhibit a lack of collagen-induced aggregation of platelets

cardiovascular system
hematoma ( J:168556 )
• greatly enlarged area of experimentally induced hematomas

homeostasis/metabolism
decreased platelet aggregation ( J:165893 )
• mutants exhibit a lack of collagen-induced aggregation of platelets

skeleton
skeleton phenotype ( J:197378 )
N
• no effect on osteoclast size and number in tibias




Genotype
MGI:2448612
hm3
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:28282 )
N
• the development of NK T cells is normal in these mice
decreased susceptibility to type I hypersensitivity reaction ( J:39248 , J:78659 )
• unable to mount a passive cutaneous anaphylactic response (J:39248)
• IgG1 dependent passive systemic anaphylaxis does not occur (J:78659)
• sensitized mice survive OVA challenge whereas controls die within 20 minutes (J:78659)
impaired macrophage phagocytosis ( J:39248 )
• phagocytosis blocked regardless of Ig binding
abnormal mast cell physiology ( J:39248 )
• loss of IgE and IgG2a binding
• IgG1 binding normal
• degranulation and serotonin release largely suppressed
• significantly reduced prostaglandin D2 release
abnormal immunoglobulin level ( J:78659 )
• serum IgG response to OVA challenge of sensitized mice more moderate than in controls (37% increase as opposed to 260%)
increased IgE level ( J:78659 )
• serum IgE response to OVA challenge of sensitized mice greater than that of controls
abnormal NK cell physiology ( J:39248 )
• antibody dependent, cell-mediated cytotoxicity almost totally lost
abnormal dendritic cell antigen presentation ( J:83995 )
• deficient antigen presentation by bone marrow dendritic cells
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:126520 )
• considerably reduced when induced with myelin oligodendrocyte glycoprotein
• more frequent disease remission
• completely protected against anaphylaxis from a second dose of myelin oligodendrocyte glycoprotein
• fewer inflammatory foci in the central nervous system

cardiovascular system
decreased myocardial infarct size ( J:112819 )
• infarct size after coronary occlusion/reperfusion is significantly reduced
• fewer platelet microthrombi and neutrophils in the capillaries of the myocardium
• occluded microthrombi in 12% of capillaries as compared to 38% in controls

homeostasis/metabolism
decreased myocardial infarct size ( J:112819 )
• infarct size after coronary occlusion/reperfusion is significantly reduced
• fewer platelet microthrombi and neutrophils in the capillaries of the myocardium
• occluded microthrombi in 12% of capillaries as compared to 38% in controls
abnormal platelet activation ( J:118488 )
• while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets
• platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets
• platelet calcium response fluctuates and is lower than in wild-type platelets
decreased platelet aggregation ( J:112819 )
• reduced aggregation in response to collagen

hematopoietic system
impaired macrophage phagocytosis ( J:39248 )
• phagocytosis blocked regardless of Ig binding
abnormal mast cell physiology ( J:39248 )
• loss of IgE and IgG2a binding
• IgG1 binding normal
• degranulation and serotonin release largely suppressed
• significantly reduced prostaglandin D2 release
abnormal immunoglobulin level ( J:78659 )
• serum IgG response to OVA challenge of sensitized mice more moderate than in controls (37% increase as opposed to 260%)
increased IgE level ( J:78659 )
• serum IgE response to OVA challenge of sensitized mice greater than that of controls
abnormal NK cell physiology ( J:39248 )
• antibody dependent, cell-mediated cytotoxicity almost totally lost
abnormal platelet activation ( J:118488 )
• while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets
• platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets
• platelet calcium response fluctuates and is lower than in wild-type platelets
decreased platelet aggregation ( J:112819 )
• reduced aggregation in response to collagen

skeleton
skeleton phenotype ( J:89583 )
N
• mice exhibit normal bone volume and osteoclast function

cellular
impaired macrophage phagocytosis ( J:39248 )
• phagocytosis blocked regardless of Ig binding




Genotype
MGI:3840591
cx4
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1Lll/Tyrobptm1Lll
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tyrobptm1Lll mutation (1 available); any Tyrobp mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal osteoclast physiology ( J:147155 )
• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

skeleton
abnormal osteoclast physiology ( J:147155 )
• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

hematopoietic system
abnormal osteoclast physiology ( J:147155 )
• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice




Genotype
MGI:3784426
cx5
Allelic
Composition		 C3tm1Crr/C3tm1Crr
Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (3 available); any C3 mutation (102 available)
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:122114 )
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG are completely protected from developing diabetes




Genotype
MGI:2448651
cx6
Allelic
Composition		 Cd247tm1Lov/Cd247tm1Lov
Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm1Lov mutation (2 available); any Cd247 mutation (11 available)
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:46914 )
• average number of thymocytes between 10 and 30% of control numbers
• almost entirely double positive or double negative
• express very low but detectable levels of TCR
absent gamma-delta intraepithelial T cell ( J:46914 )
• TCR gamma-delta T cells are virtually absent while alpha-beta lineages are readily detectable among intestinal epithelial lymphocytes
abnormal effector T cell morphology ( J:46914 )
• detectable in lymph nodes and the spleen
• a high percentage with activated or memory phenotypes
impaired natural killer cell mediated cytotoxicity ( J:64764 )
• natural cytoxicity towards YAC-1, Bw15.02, C4.4.25, RMA, and RMA/S cells is defective compared to in wild-type cells
abnormal T-helper 1 physiology ( J:46914 )
• can be stimulated to produce large quantities of interferon gamma
• can be induced to produce Il2
abnormal T cell activation ( J:46914 )
• refractory to direct TCR stimulation in vitro

hematopoietic system
decreased thymocyte number ( J:46914 )
• average number of thymocytes between 10 and 30% of control numbers
• almost entirely double positive or double negative
• express very low but detectable levels of TCR
absent gamma-delta intraepithelial T cell ( J:46914 )
• TCR gamma-delta T cells are virtually absent while alpha-beta lineages are readily detectable among intestinal epithelial lymphocytes
abnormal effector T cell morphology ( J:46914 )
• detectable in lymph nodes and the spleen
• a high percentage with activated or memory phenotypes
impaired natural killer cell mediated cytotoxicity ( J:64764 )
• natural cytoxicity towards YAC-1, Bw15.02, C4.4.25, RMA, and RMA/S cells is defective compared to in wild-type cells
abnormal T-helper 1 physiology ( J:46914 )
• can be stimulated to produce large quantities of interferon gamma
• can be induced to produce Il2
abnormal T cell activation ( J:46914 )
• refractory to direct TCR stimulation in vitro

endocrine/exocrine glands
decreased thymocyte number ( J:46914 )
• average number of thymocytes between 10 and 30% of control numbers
• almost entirely double positive or double negative
• express very low but detectable levels of TCR




Genotype
MGI:3579384
cx7
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Hexbtm1Rlp/Hexbtm1Rlp
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Hexbtm1Rlp mutation (1 available); any Hexb mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:87617 )
• survival to about 130 days of age

homeostasis/metabolism
abnormal lipid level ( J:87617 )
• ganglioside accumulation as in singly homozygous Hexbtm1Rlp

immune system
increased immunoglobulin level ( J:87617 )
• slightly elevated circulating antibody levels but less than in singly homozygous Hexbtm1Rlp

behavior/neurological
behavior/neurological phenotype ( J:87617 )
N
• able to open their limbs and move actively when lifted by their tails
impaired coordination ( J:87617 )
• improved coordination in a rotarod test relative to singly homozygous Hexbtm1Rlp until 12 weeks of age when deteriorating performance is seen

nervous system
nervous system phenotype ( J:87617 )
N
• minimal Purkinje cell degeneration

cellular
decreased apoptosis ( J:87617 )
• reduced apoptosis in the brain relative to singly homozygous Hexbtm1Rlp

hematopoietic system
increased immunoglobulin level ( J:87617 )
• slightly elevated circulating antibody levels but less than in singly homozygous Hexbtm1Rlp

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Sandhoff disease DOID:3323 OMIM:268800
 J:87617




Genotype
MGI:3818419
cx8
Allelic
Composition		 Cd247tm1Mhu/Cd247tm1Mhu
Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm1Mhu mutation (0 available); any Cd247 mutation (11 available)
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal maternal decidual layer morphology ( J:100668 )
• embryo implantation sites are hypercellular compared to in wild-type mice
• at E10 and E12, the mesometrial lymphoid aggregate of pregnancy is enlarged compared to in wild-type mice
abnormal decidua basalis morphology ( J:100668 )
• at E10, the deciduas basalis is larger compared to in wild-type mice
decreased uterine NK cell number ( J:100668 )
• the number of uterine NK cells at E10 in the mesometrial lymphoid aggregate of pregnancy and at E12 in the deciduas basalis is reduced compared to in wild-type mice
abnormal uterine spiral artery morphology ( J:100668 )
• at E10 and E12, the decidual spiral arterial vessel to lumen area is increased compared to in wild-type mice
abnormal uterine spiral artery remodeling ( J:100668 )
• at E12, thick-walled arteries are prominent in embryo implantation site unlike in wild-type mice
• uterine NK cells fail to modify the spiral arteries of the decidua as in wild-type mice
reduced fertility ( J:100668 )
• fewer mice become pregnant following mating compared to wild-type mice
• early post-implantation fetal loss (E6 and E8) is greater than in wild-type mice

embryo
abnormal maternal decidual layer morphology ( J:100668 )
• embryo implantation sites are hypercellular compared to in wild-type mice
• at E10 and E12, the mesometrial lymphoid aggregate of pregnancy is enlarged compared to in wild-type mice
abnormal decidua basalis morphology ( J:100668 )
• at E10, the deciduas basalis is larger compared to in wild-type mice
decreased uterine NK cell number ( J:100668 )
• the number of uterine NK cells at E10 in the mesometrial lymphoid aggregate of pregnancy and at E12 in the deciduas basalis is reduced compared to in wild-type mice
abnormal uterine spiral artery morphology ( J:100668 )
• at E10 and E12, the decidual spiral arterial vessel to lumen area is increased compared to in wild-type mice

immune system
decreased uterine NK cell number ( J:100668 )
• the number of uterine NK cells at E10 in the mesometrial lymphoid aggregate of pregnancy and at E12 in the deciduas basalis is reduced compared to in wild-type mice

hematopoietic system
decreased uterine NK cell number ( J:100668 )
• the number of uterine NK cells at E10 in the mesometrial lymphoid aggregate of pregnancy and at E12 in the deciduas basalis is reduced compared to in wild-type mice

endocrine/exocrine glands
decreased uterine NK cell number ( J:100668 )
• the number of uterine NK cells at E10 in the mesometrial lymphoid aggregate of pregnancy and at E12 in the deciduas basalis is reduced compared to in wild-type mice




Genotype
MGI:3840594
cx9
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Del(7Tyrobp-Hcst)1Ttk/Del(7Tyrobp-Hcst)1Ttk
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7Tyrobp-Hcst)1Ttk mutation (1 available); any Del(7Tyrobp-Hcst)1Ttk mutation (0 available)
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast physiology ( J:147155 )
• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

immune system
abnormal osteoclast physiology ( J:147155 )
• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

hematopoietic system
abnormal osteoclast physiology ( J:147155 )
• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice




Genotype
MGI:3818420
cx10
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tyrobptm1.1Viv mutation (1 available); any Tyrobp mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal maternal decidual layer morphology ( J:100668 )
• at E12, the mesometrial lymphoid aggregate of pregnancy is smaller than in wild-type mice
abnormal decidua basalis morphology ( J:100668 )
• at E10, the decidua basalis is reduced compared to in wild-type mice
decreased uterine NK cell number ( J:100668 )
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy
abnormal uterine spiral artery morphology ( J:100668 )
• at E10 and E12, the decidual spiral arterial vessel to lumen area is increased compared to in wild-type mice
abnormal uterine spiral artery remodeling ( J:100668 )
• at E12, thick-walled arteries are prominent in implantation site unlike in wild-type mice
• uterine NK cells fail to modify the spiral arteries of the deciduas as in wild-type mice
reduced fertility ( J:100668 )
• fewer mice of one line become pregnant following mating compared to wild-type mice
• midgestational (E10) fetal loss is greater than in wild-type mice
• however, mice derived from a different line exhibit normal pregnancy rates

embryo
abnormal maternal decidual layer morphology ( J:100668 )
• at E12, the mesometrial lymphoid aggregate of pregnancy is smaller than in wild-type mice
abnormal decidua basalis morphology ( J:100668 )
• at E10, the decidua basalis is reduced compared to in wild-type mice
decreased uterine NK cell number ( J:100668 )
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy
abnormal uterine spiral artery morphology ( J:100668 )
• at E10 and E12, the decidual spiral arterial vessel to lumen area is increased compared to in wild-type mice
small placenta ( J:100668 )
• at E10 and E12

immune system
decreased uterine NK cell number ( J:100668 )
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy
decreased interferon-gamma secretion ( J:100668 )
• at E6 through E14 in the mesometrial triangle, mesometrial lymphoid aggregate of pregnancy and deciduas basalis

hematopoietic system
decreased uterine NK cell number ( J:100668 )
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy

endocrine/exocrine glands
decreased uterine NK cell number ( J:100668 )
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy




Genotype
MGI:3818498
cx11
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1Lll/Tyrobptm1Lll
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tyrobptm1Lll mutation (1 available); any Tyrobp mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:89583 )
N
• unlike Src or Tnfsf11 mutants, mice develop teeth
abnormal bone structure ( J:89583 )
• bones exhibit large areas of unresorbed bone with cartilaginous streaks unlike wild-type bone
abnormal osteoclast differentiation ( J:89583 )
• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs can partially restore differentiation
abnormal trabecular bone morphology ( J:89583 )
• mice exhibit an increased in trabecular number, trabecular thickness and decreased trabecular separation compared to wild-type mice
• trabecular structures are concave and solid with tube-like channels of arrow space unlike in wild trabeculae that are rod-like
osteopetrosis ( J:89583 )
• mice exhibit a severe increase in bone volume compared to in wild-type mice
decreased bone resorption ( J:89583 )
• osteoclast fail to resorb mineralized matrix in vivo unlike wild-type cells
• treatment of osteoclast precursors with large doses of macrophage colony stimulating factor does not rescue bone resoprtion
• however, transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs partially restores osteaoclasts bone resorption

growth/size/body
round face ( J:89583 )
• rounded face
decreased body size ( J:89583 )

craniofacial
round face ( J:89583 )
• rounded face

immune system
abnormal osteoclast differentiation ( J:89583 )
• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs can partially restore differentiation

hematopoietic system
abnormal osteoclast differentiation ( J:89583 )
• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs can partially restore differentiation

limbs/digits/tail

cellular
abnormal osteoclast differentiation ( J:89583 )
• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs can partially restore differentiation




Genotype
MGI:3784425
cx12
Allelic
Composition		 Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:122114 )
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence of anti-ovalbumin IgG is abolished compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
decreased susceptibility to autoimmune diabetes ( J:122114 )
• only 40% of mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG exhibit diabetes compared to 100% of similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
• the severity of diabetes induced by Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG is reduced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

hematopoietic system
decreased T cell proliferation ( J:122114 )
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence of anti-ovalbumin IgG is abolished compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

cellular
decreased T cell proliferation ( J:122114 )
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence of anti-ovalbumin IgG is abolished compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice




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Send questions and comments to User Support. 		last database update
04/23/2024
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