Del(7Tyrobp-Hcst)1Ttk
Targeted Allele Detail

Summary

• Symbol: Del(7Tyrobp-Hcst)1Ttk
• Name: deletion, Chr 7, Toshiyuki Takai 1
• MGI ID: MGI:3840566
• Synonyms: DAP12^-DAP10^-, Del1Ttk, Hcst/Tyrobp^tm1Ttk
• Gene: Del(7Tyrobp-Hcst)1Ttk Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147155
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Tyrobp-Hcst)1Ttk involves 2 genes/genome features (Tyrobp, Hcst) View all
• Mutation details: All the exons that code for Hcst and Tyrobp were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on bone marrow derived macrophage and IL2-activated killer cell extracts. (J:147155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(7Tyrobp-Hcst)1Ttk Mutation: 0 strains or lines available

References

• Original: J:147155 Inui M, et al., Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4816-21
• All: 3 reference(s)