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Faslgld
Spontaneous Allele Detail
Nomenclature
Symbol: Faslgld
Name: Fas ligand (TNF superfamily, member 6); generalized lymphoproliferative disease
MGI ID: MGI:1856384
Synonyms: CD95-, FasL-, gld, Tnfsf6gld
Gene: Fasl  Location: Chr1:161780689-161788495 bp, - strand  Genetic Position: Chr1, 69.95 cM
control and Faslgld/Faslgld

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H/HeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 in the extracellular region of the encoded protein. (J:17445)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:  11 strains or lines available
References
Original:  J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
All:  321 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory