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Lama2dy-2J
Spontaneous Allele Detail
Nomenclature
Symbol: Lama2dy-2J
Name: laminin, alpha 2; dystrophia muscularis 2 Jackson
MGI ID: MGI:1856027
Synonyms: 2J, dy2J
Gene: Lama2  Location: Chr10:26857281-27493021 bp, - strand  Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
Lama2dy-2J/Lama2dy-2J mouse

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  WK/ReJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe G-to-A mutation eliminates a splice donor site by changing it from C-GT to C-AT, which causes abnormal splicing and expression of multiple aberrant mRNAs variants. One mRNA is translated into an alpha 2 polypeptide with a deletion in domain VI. (J:21367, J:25954)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lama2 Mutation:  107 strains or lines available
References
Original:  J:5151 Meier H, et al., Muscular dystrophy in the mouse caused by an allele at the dy-locus. Life Sci. 1970 Feb 8;9(3):137-44
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory