Tyr^c-ch
Spontaneous Allele Detail

Summary

• Symbol: Tyr^c-ch
• Name: tyrosinase; chinchilla
• MGI ID: MGI:1855977
• Synonyms: c^ch, c^r
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-ch page

Tyr^c/Tyr^c and Tyr^c/Tyr^c-ch Oca2^p/ Oca2^p

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: fancier's stock

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in the chinchilla allele was found to be a G-to-A point mutation that results in an amino acid change at position 482 or 464 from alanine to threonine (p.A482T for pre-protein, p.A464T for mature protein). (J:19279)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	7 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tyr^c-ch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 79 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 375 strains or lines available

References

• Original: J:14850 Feldman HW, A fourth allelomorph in the albino series in mice. Am Naturalist. 1922;56:573-574
• All: 43 reference(s)