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Ltbp2 Gene Detail
Summary
  • Symbol
    Ltbp2
  • Name
    latent transforming growth factor beta binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99502
    NCBI Gene: 16997
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84829986-84923306 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.39 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    550 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99502
 protein coding gene Chr12:84829986-84923581 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019946
 protein coding gene Chr12:85523484-85621849 (-)
A/J MGP_AJ_G0019903
 protein coding gene Chr12:82281272-82375664 (-)
AKR/J MGP_AKRJ_G0019879
 protein coding gene Chr12:84504784-84602556 (-)
BALB/cJ MGP_BALBcJ_G0019883
 protein coding gene Chr12:82611785-82704931 (-)
C3H/HeJ MGP_C3HHeJ_G0019689
 protein coding gene Chr12:84977901-85077192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020334
 protein coding gene Chr12:87988863-88085753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017952
 protein coding gene Chr12:79169073-79263671 (-)
CAST/EiJ MGP_CASTEiJ_G0019238
 protein coding gene Chr12:79945925-80043382 (-)
CBA/J MGP_CBAJ_G0019660
 protein coding gene Chr12:91377708-91476992 (-)
DBA/2J MGP_DBA2J_G0019775
 protein coding gene Chr12:81797850-81891950 (-)
FVB/NJ MGP_FVBNJ_G0019761
 protein coding gene Chr12:80759321-80854412 (-)
LP/J MGP_LPJ_G0019847
 protein coding gene Chr12:85398244-85496190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019800
 protein coding gene Chr12:94263849-94362155 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020368
 protein coding gene Chr12:84113425-84208338 (-)
PWK/PhJ MGP_PWKPhJ_G0019002
 protein coding gene Chr12:76288142-76383442 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018797
 protein coding gene Chr12:78582151-78681566 (-)
WSB/EiJ MGP_WSBEiJ_G0019290
 protein coding gene Chr12:84823166-84926903 (-)



Homology
more
  • Human Ortholog
    LTBP2, latent transforming growth factor beta binding protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTBP2, latent transforming growth factor beta binding protein 2
  • Synonyms
    C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3
  • Links
    NCBI Gene ID: 4053
    neXtProt AC: NX_Q14767
    UniProt: Q14767

  • Chr Location
    14q24.3; chr14:74498183-74612378 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LTBP2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit early embryonic lethality prior to E6.5. Mice homozygous for a different null allele are viable, fertile, and developmentally normal but develop lens dislocations due to ciliary zonule fragmentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    50
  • cDNA Data
    26
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002020 Ensembl Gene Model | MGI Sequence Detail 93321 C57BL/6J ±  kb
    transcript ENSMUST00000002073 Ensembl | MGI Sequence Detail 6769 Not Applicable  
    polypeptide ENSMUSP00000002073 Ensembl | MGI Sequence Detail 1809 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 27

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16278, MGI:2145013
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:37693 Nakajima Y, et al., Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol. 1997 Jan 13;136(1):193-204
    • Latest
      J:340880 Bodmer NK, et al., Multi-organ phenotypes in mice lacking latent TGFbeta binding protein 2 (LTBP2). Dev Dyn. 2023 Sep 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory