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Rbp4 Gene Detail
Summary
  • Symbol
    Rbp4
  • Name
    retinol binding protein 4, plasma
  • Synonyms
    Rbp-4, retinol binding protein 4, cellular
  • Feature Type
    protein coding gene
  • IDs
    MGI:97879
    NCBI Gene: 19662
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38105077-38113729 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.75 cM, cytoband D1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97879
 protein coding gene Chr19:38105068-38113769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025088
 protein coding gene Chr19:37137192-37145795 (-)
A/J MGP_AJ_G0025064
 protein coding gene Chr19:35334867-35343470 (-)
AKR/J MGP_AKRJ_G0025032
 protein coding gene Chr19:36536363-36544965 (-)
BALB/cJ MGP_BALBcJ_G0025062
 protein coding gene Chr19:35443478-35452081 (-)
C3H/HeJ MGP_C3HHeJ_G0024821
 protein coding gene Chr19:36608881-36617484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025503
 protein coding gene Chr19:38201352-38210041 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022922
 protein coding gene Chr19:34690403-34699062 (-)
CAST/EiJ MGP_CASTEiJ_G0024288
 protein coding gene Chr19:36477566-36486234 (-)
CBA/J MGP_CBAJ_G0024798
 protein coding gene Chr19:39982593-39991196 (-)
DBA/2J MGP_DBA2J_G0024930
 protein coding gene Chr19:35188681-35197316 (-)
FVB/NJ MGP_FVBNJ_G0024891
 protein coding gene Chr19:35001423-35010021 (-)
LP/J MGP_LPJ_G0025016
 protein coding gene Chr19:37234832-37243435 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024922
 protein coding gene Chr19:39763292-39772934 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025561
 protein coding gene Chr19:36635152-36643755 (-)
PWK/PhJ MGP_PWKPhJ_G0024040
 protein coding gene Chr19:35054520-35063224 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023840
 protein coding gene Chr19:35472162-35480751 (-)
WSB/EiJ MGP_WSBEiJ_G0024355
 protein coding gene Chr19:36717801-36726401 (-)



Homology
more
  • Human Ortholog
    RBP4, retinol binding protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBP4, retinol binding protein 4
  • Synonyms
    MCOPCB10, RDCCAS
  • Links
    NCBI Gene ID: 5950
    neXtProt AC: NX_P02753
    UniProt: P02753

  • Chr Location
    10q23.33; chr10:93591687-93601744 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RBP4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show abnormal retinal function and retinol level, delayed heart trabeculation, and increased myocyte proliferation and fibronectin deposition in cardiac jelly and nascent valves. Homozygotes for another null allele show testicular defects on a vitamin A-deficient diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    94
  • cDNA Data
    177
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024990 Ensembl Gene Model | MGI Sequence Detail 8653 C57BL/6J ±  kb
    transcript ENSMUST00000025951 Ensembl | MGI Sequence Detail 1161 Not Applicable  
    polypeptide ENSMUSP00000025951 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 185
      cDNA 179
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13790, MGD-MRK-13795
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 16
      Phenotypes 45
    • Earliest
      J:11060 Chainani M, et al., Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Genomics. 1991 Feb;9(2):376-9
    • Latest
      J:337785 Lowenstein ED, et al., Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Neuron. 2023 May 10;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory