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Hoxb3 Gene Detail
Summary
  • Symbol
    Hoxb3
  • Name
    homeobox B3
  • Synonyms
    Hox-2.7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96184
    NCBI Gene: 15410
  • Member of
    Hoxb cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96214152-96238756 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.84 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96184
 protein coding gene Chr11:96197927-96238756 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019007
 protein coding gene Chr11:98636481-98661028 (+)
A/J MGP_AJ_G0018975
 protein coding gene Chr11:94607890-94632422 (+)
AKR/J MGP_AKRJ_G0018945
 protein coding gene Chr11:97534088-97559194 (+)
BALB/cJ MGP_BALBcJ_G0018948
 protein coding gene Chr11:95107602-95131900 (+)
C3H/HeJ MGP_C3HHeJ_G0018762
 protein coding gene Chr11:97665332-97689839 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019400
 protein coding gene Chr11:101717463-101741975 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017030
 protein coding gene Chr11:92094449-92119230 (+)
CAST/EiJ MGP_CASTEiJ_G0018315
 protein coding gene Chr11:98490779-98515376 (+)
CBA/J MGP_CBAJ_G0018733
 protein coding gene Chr11:105879331-105906620 (+)
DBA/2J MGP_DBA2J_G0018841
 protein coding gene Chr11:94175346-94199845 (+)
FVB/NJ MGP_FVBNJ_G0018830
 protein coding gene Chr11:93654056-93678490 (+)
LP/J MGP_LPJ_G0018911
 protein coding gene Chr11:99172528-99196941 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018857
 protein coding gene Chr11:105874853-105902041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019440
 protein coding gene Chr11:97841531-97866001 (+)
PWK/PhJ MGP_PWKPhJ_G0018087
 protein coding gene Chr11:95126978-95151890 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017876
 protein coding gene Chr11:97568889-97593572 (+)
WSB/EiJ MGP_WSBEiJ_G0018365
 protein coding gene Chr11:97729792-97755961 (+)



Homology
more
  • Human Ortholog
    HOXB3, homeobox B3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXB3, homeobox B3
  • Synonyms
    HOX2, Hox-2.7, HOX2G
  • Links
    NCBI Gene ID: 3213
    neXtProt AC: NX_P14651
    UniProt: P14651

  • Chr Location
    17q21.32; chr17:48548870-48604912 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    32 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display partial neonatal lethality and mild and low penetrance defects in the formation of the anterior arch of the atlas and the IXth cranial nerve.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1134
  • Tissues
    206
  • cDNA Data
    21
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048763 Ensembl Gene Model | MGI Sequence Detail 24605 C57BL/6J ±  kb
    transcript ENSMUST00000093944 Ensembl | MGI Sequence Detail 3190 Not Applicable  
    polypeptide ENSMUSP00000091476 Ensembl | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 7
      cDNA 23
      Primer pair 9
      Other 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10835, MGD-MRK-10885
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 72
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
    • Latest
      J:334461 De Bono C, et al., Single-cell transcriptomics uncovers a non-autonomous Tbx1-dependent genetic program controlling cardiac neural crest cell development. Nat Commun. 2023 Mar 21;14(1):1551
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory