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Crygc Gene Detail
Summary
  • Symbol
    Crygc
  • Name
    crystallin, gamma C
  • Synonyms
    Cryg-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88523
    NCBI Gene: 12966
  • Member of
    Cryg cluster
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65110684-65112691 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88523
 protein coding gene Chr1:65110684-65112848 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016103
 protein coding gene Chr1:65263612-65267852 (-)
A/J MGP_AJ_G0016086
 protein coding gene Chr1:62967784-62970150 (-)
AKR/J MGP_AKRJ_G0016043
 protein coding gene Chr1:64730195-64732359 (-)
BALB/cJ MGP_BALBcJ_G0016041
 protein coding gene Chr1:63063598-63065762 (-)
C3H/HeJ MGP_C3HHeJ_G0015872
 protein coding gene Chr1:65002815-65006260 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016494
 protein coding gene Chr1:67792635-67794799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014215
 protein coding gene Chr1:59021160-59023325 (-)
CAST/EiJ MGP_CASTEiJ_G0015456
 protein coding gene Chr1:64274342-64276517 (-)
CBA/J MGP_CBAJ_G0015845
 protein coding gene Chr1:69997329-69999493 (-)
DBA/2J MGP_DBA2J_G0015946
 protein coding gene Chr1:62369104-62371268 (-)
FVB/NJ MGP_FVBNJ_G0015949
 protein coding gene Chr1:61642812-61645123 (-)
LP/J MGP_LPJ_G0016018
 protein coding gene Chr1:66166664-66170908 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015969
 protein coding gene Chr1:72847329-72849715 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016541
 protein coding gene Chr1:64716563-64718964 (-)
PWK/PhJ MGP_PWKPhJ_G0015242
 protein coding gene Chr1:61768826-61770990 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015022
 protein coding gene Chr1:64199871-64202030 (-)
WSB/EiJ MGP_WSBEiJ_G0015518
 protein coding gene Chr1:64422881-64425045 (-)



Homology
more
  • Human Ortholog
    CRYGC, crystallin gamma C
  • Vertebrate Orthologs
    32
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGC, crystallin gamma C
  • Synonyms
    CCL, CRYG3, CTRCT2
  • Links
    NCBI Gene ID: 1420
    neXtProt AC: NX_P07315
    UniProt: P07315

  • Chr Location
    2q33.3; chr2:208128137-208129828 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crygc mouse models; 2 with human CRYGC associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 6 genetic backgrounds
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes and heterozygotes for a chlorambucil-induced mutation exhibit a nuclear and radial cataract characterized by persistence of the lens fiber cell nuclei. Homozygotes present a more severe cataract with mild microphthalmia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    20
  • cDNA Data
    83
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12966 NCBI Gene Model | MGI Sequence Detail 2008 C57BL/6J ±  kb
    transcript NM_001082573 RefSeq | MGI Sequence Detail 629 ZRU/MplStud  
    polypeptide Q61597 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 1
      cDNA 83
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2174, MGD-MRK-2178
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:341260 Minogue PJ, et al., A crystallin mutant cataract with mineral deposits. J Biol Chem. 2023 Jun 17;299(8):104935
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory