Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Nrltm1.1Jcco Name: neural retina leucine zipper gene; targeted mutation 1.1, Joseph C Corbo MGI ID: MGI:5490568 Synonyms: NrlCKO Gene: Nrl  Location: Chr14:55756972-55762438 bp, - strand  Genetic Position: Chr14, 28.19 cM Alliance: Nrltm1.1Jcco page

Adult rods are reprogrammed into cone-like cells in Nrltm1.1Jcco/Nrltm1.1Jcco and Nrltm1Asw/Nrltm1Asw retinas Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:193697
Parent Cell Line:	SCC10 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed the floxed exon 3. In situ hybridization confirmed lack of transcript expression in the retina. (J:193697)

Generation of the Nrltm1Jcco and Nrltm1.1Jcco alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrl Mutation:	17 strains or lines available

Original:	J:193697 Montana CL, et al., Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1732-7
All:	1 reference(s)