Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Notch2tm2Grid
Name:	notch 2; targeted mutation 2, Tom Gridley
MGI ID:	MGI:3617327
Synonyms:	Notch2del2
Gene:	Notch2  Location: Chr3:97920854-98057683 bp, + strand  Genetic Position: Chr3, 42.42 cM
Alliance:	Notch2tm2Grid page

Germline Transmission:	Earliest citation of germline transmission: J:105278
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A betagalactosidase-neo cassette replaced the exon 3 splice donor site and most of intron 3. The lacZ was inserted in frame with amino acid 118 in the third EGF repeat of the extracellular domain. RT-PCR detected two small transcripts expressed at low levels, resulting from alternative splicing around the inserted sequence. (J:105278)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:	97 strains or lines available

Original:	J:105278 McCright B, et al., Generation of new Notch2 mutant alleles. Genesis. 2006 Jan;44(1):29-33
All:	3 reference(s)