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Cd226 Gene Detail
Summary
  • Symbol
    Cd226
  • Name
    CD226 antigen
  • Synonyms
    DNAM1, DNAM-1, Pta1, TLiSA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039602
    NCBI Gene: 225825
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:89195091-89290353 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 59.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039602
 protein coding gene Chr18:89195078-89290356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024617
 protein coding gene Chr18:90548695-90624119 (+)
A/J MGP_AJ_G0024584
 protein coding gene Chr18:86507990-86581496 (+)
AKR/J MGP_AKRJ_G0024555
 protein coding gene Chr18:89113190-89189656 (+)
BALB/cJ MGP_BALBcJ_G0024582
 protein coding gene Chr18:86782706-86858218 (+)
C3H/HeJ MGP_C3HHeJ_G0024351
 protein coding gene Chr18:89264711-89339948 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025030
 protein coding gene Chr18:92855606-92932451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022460
 protein coding gene Chr18:85237912-85311902 (+)
CAST/EiJ MGP_CASTEiJ_G0023823
 protein coding gene Chr18:89734141-89811753 (+)
CBA/J MGP_CBAJ_G0024321
 protein coding gene Chr18:96166301-96250301 (+)
DBA/2J MGP_DBA2J_G0024450
 protein coding gene Chr18:86060785-86138025 (+)
FVB/NJ MGP_FVBNJ_G0024417
 protein coding gene Chr18:85387304-85467761 (+)
LP/J MGP_LPJ_G0024535
 protein coding gene Chr18:90408799-90485890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024447
 protein coding gene Chr18:98024457-98125712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025078
 protein coding gene Chr18:89410739-89486044 (+)
PWK/PhJ MGP_PWKPhJ_G0023569
 protein coding gene Chr18:86425863-86500262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023376
 protein coding gene Chr18:89394149-89472997 (+)
WSB/EiJ MGP_WSBEiJ_G0023886
 protein coding gene Chr18:89315647-89391864 (+)



Homology
more
  • Human Ortholog
    CD226, CD226 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD226, CD226 molecule
  • Synonyms
    DNAM1, DNAM-1, PTA1, TLiSA1
  • Links
    NCBI Gene ID: 10666
    neXtProt AC: NX_Q15762
    UniProt: Q15762

  • Chr Location
    18q22.2; chr18:69831158-69961803 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and increased incidence of tumor formation and mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034028 Ensembl Gene Model | MGI Sequence Detail 95263 C57BL/6J ±  kb
transcript ENSMUST00000236828 Ensembl | MGI Sequence Detail 4494 Not Applicable  
polypeptide ENSMUSP00000158324 Ensembl | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 77
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 37
  • Earliest
    J:79321 Sherrington PD, et al., TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. J Biol Chem. 1997 Aug 29;272(35):21735-44
  • Latest
    J:346403 Qiao W, et al., Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model. J Invest Dermatol. 2024 Feb 6;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory