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Nuggc Gene Detail
Summary
  • Symbol
    Nuggc
  • Name
    nuclear GTPase, germinal center associated
  • Synonyms
    Gm600, LOC239151, SLIP-GC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685446
    NCBI Gene: 100503545
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:65835995-65885980 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    460 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685446
 protein coding gene Chr14:65830901-65885980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021482
 protein coding gene Chr14:60212235-60268323 (+)
A/J MGP_AJ_G0021441
 protein coding gene Chr14:58817808-58868492 (+)
AKR/J MGP_AKRJ_G0021417
 protein coding gene Chr14:60858849-60911007 (+)
BALB/cJ MGP_BALBcJ_G0021447
 protein coding gene Chr14:58753605-58804971 (+)
C3H/HeJ MGP_C3HHeJ_G0021224
 protein coding gene Chr14:60497882-60551266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021886
 protein coding gene Chr14:62989430-63046348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019426
 protein coding gene Chr14:56748395-56799478 (+)
CAST/EiJ MGP_CASTEiJ_G0020741
 protein coding gene Chr14:56984319-57037878 (+)
CBA/J MGP_CBAJ_G0021191
 protein coding gene Chr14:64893111-64952000 (+)
DBA/2J MGP_DBA2J_G0021314
 protein coding gene Chr14:58466047-58516988 (+)
FVB/NJ MGP_FVBNJ_G0021293
 protein coding gene Chr14:57866027-57916596 (+)
LP/J MGP_LPJ_G0021389
 protein coding gene Chr14:61246910-61304902 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021322
 protein coding gene Chr14:63995133-64053048 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021909
 protein coding gene Chr14:60038812-60093488 (+)
PWK/PhJ MGP_PWKPhJ_G0020485
 protein coding gene Chr14:55177199-55229829 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020318
 protein coding gene Chr14:56003504-56066643 (+)
WSB/EiJ MGP_WSBEiJ_G0020794
 protein coding gene Chr14:60347686-60401273 (+)



Homology
more
  • Human Ortholog
    NUGGC, nuclear GTPase, germinal center associated
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUGGC, nuclear GTPase, germinal center associated
  • Synonyms
    C8orf80, HMFN0672, SLIPGC, SLIP-GC
  • Links
    NCBI Gene ID: 389643
    neXtProt AC: NX_Q68CJ6
    UniProt: Q68CJ6

  • Chr Location
    8p21.1; chr8:28021964-28083936 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased somatic mutation frequency immunoglobulin and non-immunoglobulin loci in B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061356 Ensembl Gene Model | MGI Sequence Detail 49986 C57BL/6J ±  kb
    transcript ENSMUST00000079469 Ensembl | MGI Sequence Detail 2567 Not Applicable  
    polypeptide ENSMUSP00000078434 Ensembl | MGI Sequence Detail 812 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:190402 Richter K, et al., Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. J Biol Chem. 2012 Sep 14;287(38):31856-65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory