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Dusp5 Gene Detail
Summary
  • Symbol
    Dusp5
  • Name
    dual specificity phosphatase 5
  • Synonyms
    LOC240672
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685183
    NCBI Gene: 240672
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53517576-53530240 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 47.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685183
 protein coding gene Chr19:53517540-53530862 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025247
 protein coding gene Chr19:53681735-53694761 (+)
A/J MGP_AJ_G0025223
 protein coding gene Chr19:51033018-51046257 (+)
AKR/J MGP_AKRJ_G0025192
 protein coding gene Chr19:52631191-52646547 (+)
BALB/cJ MGP_BALBcJ_G0025218
 protein coding gene Chr19:51117412-51131014 (+)
C3H/HeJ MGP_C3HHeJ_G0024978
 protein coding gene Chr19:52856834-52870173 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025661
 protein coding gene Chr19:54972444-54988696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023073
 protein coding gene Chr19:50028450-50041444 (+)
CAST/EiJ MGP_CASTEiJ_G0024443
 protein coding gene Chr19:52821696-52836515 (+)
CBA/J MGP_CBAJ_G0024958
 protein coding gene Chr19:57703256-57716448 (+)
DBA/2J MGP_DBA2J_G0025090
 protein coding gene Chr19:50845494-50858587 (+)
FVB/NJ MGP_FVBNJ_G0025051
 protein coding gene Chr19:50545248-50558266 (+)
LP/J MGP_LPJ_G0025176
 protein coding gene Chr19:53544564-53558974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025084
 protein coding gene Chr19:57156684-57170020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025719
 protein coding gene Chr19:52830502-52843603 (+)
PWK/PhJ MGP_PWKPhJ_G0024191
 protein coding gene Chr19:50750659-50764026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023994
 protein coding gene Chr19:51504870-51517852 (+)
WSB/EiJ MGP_WSBEiJ_G0024513
 protein coding gene Chr19:52967652-52980822 (+)



Homology
more
  • Human Ortholog
    DUSP5, dual specificity phosphatase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP5, dual specificity phosphatase 5
  • Synonyms
    DUSP, HVH3
  • Links
    NCBI Gene ID: 1847
    neXtProt AC: NX_Q16690
    UniProt: Q16690

  • Chr Location
    10q25.2; chr10:110497907-110511533 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased proliferation and apoptosis and altered metabolic profiles in T cells. Mice homozygous for other null alleles exhibit altered eosinophilic response to parasicitc infection and increased susceptibility to induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    16
  • cDNA Data
    5
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240672 NCBI Gene Model | MGI Sequence Detail 12665 C57BL/6J ±  kb
transcript NM_001085390 RefSeq | MGI Sequence Detail 1815 C57BL/6  
polypeptide NP_001078859 RefSeq | MGI Sequence Detail 384 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    3.1.3.16, 3.1.3.48
  • InterPro Domains
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR001763 Rhodanese-like domain
    IPR036873 Rhodanese-like domain superfamily
    IPR000387 Tyrosine-specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
  • Latest
    J:324774 Kidger AM, et al., Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene. 2022 May;41(20):2811-2823
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory