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Il22ra1 Gene Detail
Summary
  • Symbol
    Il22ra1
  • Name
    interleukin 22 receptor, alpha 1
  • Synonyms
    Il22r
  • Feature Type
    protein coding gene
  • IDs
    MGI:2663588
    NCBI Gene: 230828
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135455483-135479451 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 67.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2663588
 protein coding gene Chr4:135455470-135482694 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028948
 protein coding gene Chr4:138191892-138216214 (+)
A/J MGP_AJ_G0028907
 protein coding gene Chr4:132342543-132366496 (+)
AKR/J MGP_AKRJ_G0028859
 protein coding gene Chr4:136159428-136183484 (+)
BALB/cJ MGP_BALBcJ_G0028931
 protein coding gene Chr4:133002192-133026146 (+)
C3H/HeJ MGP_C3HHeJ_G0028645
 protein coding gene Chr4:136429145-136454397 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029372
 protein coding gene Chr4:143112890-143138814 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026643
 protein coding gene Chr4:125395924-125420049 (+)
CAST/EiJ MGP_CASTEiJ_G0028077
 protein coding gene Chr4:134558808-134585670 (+)
CBA/J MGP_CBAJ_G0028610
 protein coding gene Chr4:147032924-147056979 (+)
DBA/2J MGP_DBA2J_G0028759
 protein coding gene Chr4:132757319-132781337 (+)
FVB/NJ MGP_FVBNJ_G0028726
 protein coding gene Chr4:131683887-131707839 (+)
LP/J MGP_LPJ_G0028858
 protein coding gene Chr4:138288588-138312918 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028752
 protein coding gene Chr4:151326306-151350242 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029410
 protein coding gene Chr4:136611013-136637546 (+)
PWK/PhJ MGP_PWKPhJ_G0027797
 protein coding gene Chr4:129535448-129559622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027623
 protein coding gene Chr4:132430922-132455010 (+)
WSB/EiJ MGP_WSBEiJ_G0028155
 protein coding gene Chr4:136779284-136805885 (+)



Homology
more
  • Human Ortholog
    IL22RA1, interleukin 22 receptor subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL22RA1, interleukin 22 receptor subunit alpha 1
  • Synonyms
    CRF2-9, IL22R, IL22R1
  • Links
    NCBI Gene ID: 58985
    neXtProt AC: NX_Q8N6P7
    UniProt: Q8N6P7

  • Chr Location
    1p36.11; chr1:24119771-24143140 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    5
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037157 Ensembl Gene Model | MGI Sequence Detail 23969 C57BL/6J ±  kb
    transcript ENSMUST00000102546 Ensembl | MGI Sequence Detail 2569 Not Applicable  
    polypeptide ENSMUSP00000099605 Ensembl | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 9
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:338066 Parrish-Novak J, et al., Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 2002 Dec 6;277(49):47517-23
    • Latest
      J:340765 Beppu AK, et al., Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection. Nat Commun. 2023 Sep 19;14(1):5814
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory