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Adcy10 Gene Detail
Summary
  • Symbol
    Adcy10
  • Name
    adenylate cyclase 10
  • Synonyms
    4930431D04Rik, sAC, Sacy, soluble adenylyl cyclase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660854
    NCBI Gene: 271639
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165312752-165404343 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 72.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    764 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2660854
 protein coding gene Chr1:165309114-165404347 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016694
 protein coding gene Chr1:170979177-171066816 (+)
A/J MGP_AJ_G0016675
 protein coding gene Chr1:163995616-164084400 (+)
AKR/J MGP_AKRJ_G0016641
 protein coding gene Chr1:168956566-169047110 (+)
BALB/cJ MGP_BALBcJ_G0016636
 protein coding gene Chr1:164490933-164578913 (+)
C3H/HeJ MGP_C3HHeJ_G0016460
 protein coding gene Chr1:169177320-169263481 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017097
 protein coding gene Chr1:176705921-176802545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014806
 protein coding gene Chr1:155894948-155983727 (+)
CAST/EiJ MGP_CASTEiJ_G0016040
 protein coding gene Chr1:168797998-168891338 (+)
CBA/J MGP_CBAJ_G0016435
 protein coding gene Chr1:182986325-183070230 (+)
DBA/2J MGP_DBA2J_G0016541
 protein coding gene Chr1:162881868-162967763 (+)
FVB/NJ MGP_FVBNJ_G0016539
 protein coding gene Chr1:161322440-161408443 (+)
LP/J MGP_LPJ_G0016612
 protein coding gene Chr1:172028968-172126224 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016564
 protein coding gene Chr1:190484130-190581032 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017133
 protein coding gene Chr1:168817100-168908532 (+)
PWK/PhJ MGP_PWKPhJ_G0015826
 protein coding gene Chr1:162085230-162171057 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015613
 protein coding gene Chr1:167664829-167754399 (+)
WSB/EiJ MGP_WSBEiJ_G0016102
 protein coding gene Chr1:168972445-169060817 (+)



Homology
more
  • Human Ortholog
    ADCY10, adenylate cyclase 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCY10, adenylate cyclase 10
  • Synonyms
    HCA2, HEL-S-7a, hsAC, SAC, SACI, Sacy
  • Links
    NCBI Gene ID: 55811
    neXtProt AC: NX_Q96PN6
    UniProt: Q96PN6

  • Chr Location
    1q24.2; chr1:167809386-167914215 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mutants are infertile with a severe sperm motility defect, female null mutants are fertile. Females exhibit increased cholesterol and triglyceride levels while both sexes have a slight increase in heart rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    126
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026567 Ensembl Gene Model | MGI Sequence Detail 91592 C57BL/6J ±  kb
    transcript ENSMUST00000027852 Ensembl | MGI Sequence Detail 5210 Not Applicable  
    polypeptide ENSMUSP00000027852 Ensembl | MGI Sequence Detail 1614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1859518, MGI:1921027
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 29
    • Earliest
      J:61511 Sinclair ML, et al., Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev. 2000 May;56(1):6-11
    • Latest
      J:343821 Ritagliati C, et al., In vivo characterization of sAC null sperm. Front Cell Dev Biol. 2023;11:1134051
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory