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Dmrt3 Gene Detail
Summary
  • Symbol
    Dmrt3
  • Name
    doublesex and mab-3 related transcription factor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449470
    NCBI Gene: 240590
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:25587665-25601285 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 20.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449470
 protein coding gene Chr19:25587609-25601285 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025003
 protein coding gene Chr19:23921417-23934660 (+)
A/J MGP_AJ_G0024980
 protein coding gene Chr19:22619942-22633309 (+)
AKR/J MGP_AKRJ_G0024948
 protein coding gene Chr19:23480093-23493421 (+)
BALB/cJ MGP_BALBcJ_G0024979
 protein coding gene Chr19:22665996-22679690 (+)
C3H/HeJ MGP_C3HHeJ_G0024735
 protein coding gene Chr19:23467493-23480853 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025420
 protein coding gene Chr19:24652798-24667619 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022839
 protein coding gene Chr19:22741352-22754667 (+)
CAST/EiJ MGP_CASTEiJ_G0024205
 protein coding gene Chr19:23211898-23225355 (+)
CBA/J MGP_CBAJ_G0024713
 protein coding gene Chr19:25724348-25737707 (+)
DBA/2J MGP_DBA2J_G0024845
 protein coding gene Chr19:22613581-22626939 (+)
FVB/NJ MGP_FVBNJ_G0024807
 protein coding gene Chr19:22515069-22528965 (+)
LP/J MGP_LPJ_G0024930
 protein coding gene Chr19:23871870-23885170 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024834
 protein coding gene Chr19:25703914-25717302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025475
 protein coding gene Chr19:23500646-23515121 (+)
PWK/PhJ MGP_PWKPhJ_G0023953
 protein coding gene Chr19:22254176-22268108 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023757
 protein coding gene Chr19:22766258-22779709 (+)
WSB/EiJ MGP_WSBEiJ_G0024272
 protein coding gene Chr19:23523860-23538273 (+)



Homology
more
  • Human Ortholog
    DMRT3, doublesex and mab-3 related transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMRT3, doublesex and mab-3 related transcription factor 3
  • Synonyms
    DMRTA3
  • Links
    NCBI Gene ID: 58524
    neXtProt AC: NX_Q9NQL9
    UniProt: Q9NQL9

  • Chr Location
    9p24.3; chr9:976655-991732 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die from starvation at 2 months of age due to dental malocclusions; some males exhibit defects in sexual development. Mutant mice also exhibit locomotor abnormalities. Mice homozygous for a different knock-out allele exhibit decreased neocortex area.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    177
  • cDNA Data
    8
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042372 Ensembl Gene Model | MGI Sequence Detail 13621 C57BL/6J ±  kb
    transcript ENSMUST00000048935 Ensembl | MGI Sequence Detail 2391 Not Applicable  
    polypeptide ENSMUSP00000046812 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 8
      Primer pair 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 34
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
    • Latest
      J:344548 Vieillard J, et al., Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei. J Comp Neurol. 2023 Jan;531(1):5-24
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory