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Plpp7 Gene Detail
Summary
  • Symbol
    Plpp7
  • Name
    phospholipid phosphatase 7 (inactive)
  • Synonyms
    D830019K17Rik, NET39, Ppapdc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445183
    NCBI Gene: 227721
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31985540-32000827 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445183
 protein coding gene Chr2:31985540-32000832 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025596
 protein coding gene Chr2:30510271-30526975 (+)
A/J MGP_AJ_G0025574
 protein coding gene Chr2:29233544-29249537 (+)
AKR/J MGP_AKRJ_G0025543
 protein coding gene Chr2:30246552-30261616 (+)
BALB/cJ MGP_BALBcJ_G0025570
 protein coding gene Chr2:29356581-29372442 (+)
C3H/HeJ MGP_C3HHeJ_G0025331
 protein coding gene Chr2:30156886-30173512 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026015
 protein coding gene Chr2:31459259-31475855 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023423
 protein coding gene Chr2:27974259-27989577 (+)
CAST/EiJ MGP_CASTEiJ_G0024793
 protein coding gene Chr2:30095013-30112198 (+)
CBA/J MGP_CBAJ_G0025308
 protein coding gene Chr2:32626987-32652019 (+)
DBA/2J MGP_DBA2J_G0025441
 protein coding gene Chr2:29006180-29021273 (+)
FVB/NJ MGP_FVBNJ_G0025404
 protein coding gene Chr2:28863461-28882530 (+)
LP/J MGP_LPJ_G0025527
 protein coding gene Chr2:30394686-30410256 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025434
 protein coding gene Chr2:32308241-32326288 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026073
 protein coding gene Chr2:30153670-30169966 (+)
PWK/PhJ MGP_PWKPhJ_G0024540
 protein coding gene Chr2:28903452-28918978 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024340
 protein coding gene Chr2:30298226-30318297 (+)
WSB/EiJ MGP_WSBEiJ_G0024861
 protein coding gene Chr2:30329790-30345053 (+)



Homology
more
  • Human Ortholog
    PLPP7, phospholipid phosphatase 7 (inactive)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLPP7, phospholipid phosphatase 7 (inactive)
  • Synonyms
    C9orf67, NET39, PPAPDC3
  • Links
    NCBI Gene ID: 84814
    neXtProt AC: NX_Q8NBV4
    UniProt: Q8NBV4

  • Chr Location
    9q34.13; chr9:131289459-131359022 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects metabolism and nuclear envelope and sarcomere structure in muscle cells, leading to muscle weakness, stunted postnatal growth and lethality before weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    23
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227721 NCBI Gene Model | MGI Sequence Detail 15288 C57BL/6J ±  kb
    transcript NM_001355238 RefSeq | MGI Sequence Detail 2073 C57BL/6  
    polypeptide Q91WB2 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030220 inactive phospholipid phosphatase 7
      (term hierarchy)
    • InterPro Domains
      IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
      IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:302139 Ramirez-Martinez A, et al., The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Nat Commun. 2021 Jan 29;12(1):690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory