About   Help   FAQ
Endov Gene Detail
Summary
  • Symbol
    Endov
  • Name
    endonuclease V
  • Synonyms
    A730011L01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444688
    NCBI Gene: 338371
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119382173-119402263 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444688
 protein coding gene Chr11:119382173-119402291 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019483
 protein coding gene Chr11:123897492-123917814 (+)
A/J MGP_AJ_G0019451
 protein coding gene Chr11:118394599-118412751 (+)
AKR/J MGP_AKRJ_G0019421
 protein coding gene Chr11:121957455-121975511 (+)
BALB/cJ MGP_BALBcJ_G0019426
 protein coding gene Chr11:118751759-118772155 (+)
C3H/HeJ MGP_C3HHeJ_G0019232
 protein coding gene Chr11:122283381-122303813 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019875
 protein coding gene Chr11:127661579-127681553 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017500
 protein coding gene Chr11:115390012-115408486 (+)
CAST/EiJ MGP_CASTEiJ_G0018786
 protein coding gene Chr11:123755379-123783005 (+)
CBA/J MGP_CBAJ_G0019203
 protein coding gene Chr11:132639142-132661608 (+)
DBA/2J MGP_DBA2J_G0019315
 protein coding gene Chr11:117765180-117785247 (+)
FVB/NJ MGP_FVBNJ_G0019307
 protein coding gene Chr11:117441612-117459611 (+)
LP/J MGP_LPJ_G0019387
 protein coding gene Chr11:124214522-124236009 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019340
 protein coding gene Chr11:131545459-131564137 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019914
 protein coding gene Chr11:122640076-122660734 (+)
PWK/PhJ MGP_PWKPhJ_G0018552
 protein coding gene Chr11:119174079-119194430 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018344
 protein coding gene Chr11:122400523-122422227 (+)
WSB/EiJ MGP_WSBEiJ_G0018838
 protein coding gene Chr11:122628883-122646797 (+)



Homology
more
  • Human Ortholog
    ENDOV, endonuclease V
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENDOV, endonuclease V
  • Links
    NCBI Gene ID: 284131
    neXtProt AC: NX_Q8N8Q3
    UniProt: Q8N8Q3

  • Chr Location
    17q25.3; chr17:80415165-80438086 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit fewer and smaller liver tumors when chemically-induced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    65
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039850 Ensembl Gene Model | MGI Sequence Detail 20091 C57BL/6J ±  kb
transcript ENSMUST00000106244 Ensembl | MGI Sequence Detail 5070 Not Applicable  
polypeptide ENSMUSP00000101851 Ensembl | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:293118 Kong XY, et al., Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Nucleic Acids Res. 2020 May 7;48(8):4463-4479
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory