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Dpp9 Gene Detail
Summary
  • Symbol
    Dpp9
  • Name
    dipeptidylpeptidase 9
  • Synonyms
    6430584G11Rik, DPRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443967
    NCBI Gene: 224897
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56493807-56525905 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443967
 protein coding gene Chr17:56493674-56525927 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023918
 protein coding gene Chr17:57840968-57873161 (-)
A/J MGP_AJ_G0023877
 protein coding gene Chr17:56276543-56310217 (-)
AKR/J MGP_AKRJ_G0023847
 protein coding gene Chr17:56950036-56985863 (-)
BALB/cJ MGP_BALBcJ_G0023879
 protein coding gene Chr17:56100654-56132421 (-)
C3H/HeJ MGP_C3HHeJ_G0023642
 protein coding gene Chr17:57661579-57694752 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024323
 protein coding gene Chr17:60120487-60155569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021770
 protein coding gene Chr17:52773545-52806771 (-)
CAST/EiJ MGP_CASTEiJ_G0023125
 protein coding gene Chr17:57975178-58007293 (-)
CBA/J MGP_CBAJ_G0023619
 protein coding gene Chr17:62419489-62456308 (-)
DBA/2J MGP_DBA2J_G0023747
 protein coding gene Chr17:54992447-55024765 (-)
FVB/NJ MGP_FVBNJ_G0023713
 protein coding gene Chr17:54515676-54549222 (-)
LP/J MGP_LPJ_G0023827
 protein coding gene Chr17:58540502-58574504 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023740
 protein coding gene Chr17:61968808-62003723 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024368
 protein coding gene Chr17:57328328-57361986 (-)
PWK/PhJ MGP_PWKPhJ_G0022870
 protein coding gene Chr17:54340637-54373879 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022682
 protein coding gene Chr17:54097687-54129660 (-)
WSB/EiJ MGP_WSBEiJ_G0023189
 protein coding gene Chr17:57939167-57971270 (-)



Homology
more
  • Human Ortholog
    DPP9, dipeptidyl peptidase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPP9, dipeptidyl peptidase 9
  • Synonyms
    DP9, DPLP9, DPP IX, DPRP2, DPRP-2, HATIS, IMD111
  • Links
    NCBI Gene ID: 91039
    neXtProt AC: NX_Q86TI2
    UniProt: Q86TI2

  • Chr Location
    19p13.3; chr19:4674341-4724673 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPP9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display partial neonatal lethality and complete lethality at preweaning stages with defects suckling due to undeveveloped tongue muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    22
  • cDNA Data
    72
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001229 Ensembl Gene Model | MGI Sequence Detail 32099 C57BL/6J ±  kb
    transcript ENSMUST00000038794 Ensembl | MGI Sequence Detail 3374 Not Applicable  
    polypeptide ENSMUSP00000046604 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 72
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:336811 Harapas CR, et al., DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Sci Immunol. 2022 Sep 16;7(75):eabi4611
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory