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Frmd6 Gene Detail
Summary
  • Symbol
    Frmd6
  • Name
    FERM domain containing 6
  • Synonyms
    2610019M19Rik, 4930488L10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442579
    NCBI Gene: 319710
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:70872288-70949008 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 29.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    681 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442579
 protein coding gene Chr12:70872235-70949009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019811
 protein coding gene Chr12:70594925-70673862 (+)
A/J MGP_AJ_G0019769
 protein coding gene Chr12:67959438-68036506 (+)
AKR/J MGP_AKRJ_G0019745
 protein coding gene Chr12:69989726-70070610 (+)
BALB/cJ MGP_BALBcJ_G0019749
 protein coding gene Chr12:68416413-68493515 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0020201
 protein coding gene Chr12:72851324-72932906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017821
 protein coding gene Chr12:65475167-65549628 (+)
CAST/EiJ MGP_CASTEiJ_G0019106
 protein coding gene Chr12:65221496-65299915 (+)
CBA/J MGP_CBAJ_G0019524
 protein coding gene Chr12:75540889-75623665 (+)
DBA/2J MGP_DBA2J_G0019640
 protein coding gene Chr12:67864938-67942159 (+)
FVB/NJ MGP_FVBNJ_G0019627
 protein coding gene Chr12:66763708-66842618 (+)
LP/J MGP_LPJ_G0019712
 protein coding gene Chr12:70585638-70663583 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0020236
 protein coding gene Chr12:69488825-69567831 (+)
PWK/PhJ MGP_PWKPhJ_G0018871
 protein coding gene Chr12:62148036-62226922 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018666
 protein coding gene Chr12:63861854-63938551 (+)
WSB/EiJ MGP_WSBEiJ_G0019157
 protein coding gene Chr12:70097424-70176316 (+)



Homology
more
  • Human Ortholog
    FRMD6, FERM domain containing 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRMD6, FERM domain containing 6
  • Synonyms
    c14_5320, C14orf31, EX1, Willin
  • Links
    NCBI Gene ID: 122786
    neXtProt AC: NX_Q96NE9
    UniProt: Q96NE9

  • Chr Location
    14q22.1; chr14:51396431-51730727 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    6
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048285 Ensembl Gene Model | MGI Sequence Detail 76721 C57BL/6J ±  kb
    transcript ENSMUST00000057859 Ensembl | MGI Sequence Detail 4662 Not Applicable  
    polypeptide ENSMUSP00000052202 Ensembl | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919400, MGI:2145018
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:282571 Zhang Z, et al., Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons. Exp Neurol. 2019 Dec;322:113055
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory