Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Atf4tm1Tow Name: activating transcription factor 4; targeted mutation 1, Timothy Townes MGI ID: MGI:2180373 Synonyms: Atf4-, Atf4 KO, Atf4tm1Tmt Gene: Atf4  Location: Chr15:80139385-80141742 bp, + strand  Genetic Position: Chr15, 37.85 cM Alliance: Atf4tm1Tow page

Atf4tm1Tow/Atf4tm1Tow mice show pancreatic hypotrophy Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:74479
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3, comprising the entire coding region, were replaced with a targeting construct containing a neomycin resistance gene. Expression analysis confirmed the absence of transcript in homozygous mutant mice. (J:74479)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atf4 Mutation:	21 strains or lines available

Original:	J:74479 Masuoka HC, et al., Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 2002 Feb 1;99(3):736-45
All:	41 reference(s)