Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gria2tm2Rsp
Name:	glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 2, Rolf Sprengel
MGI ID:	MGI:2178121
Synonyms:	GluR-Bneo
Gene:	Gria2  Location: Chr3:80588757-80710142 bp, - strand  Genetic Position: Chr3, 35.5 cM
Alliance:	Gria2tm2Rsp page

Germline Transmission:	Earliest citation of germline transmission: J:51845
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The editing site complementary sequence (ECS) in intron 11 was replaced with a loxP-flanked neomycin resistance cassette. Northern blot and in situ hybridization analysis demonstrated that low levels of unedited transcripts were produced from this allele. (J:51845)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria2 Mutation:	75 strains or lines available

Original:	J:51845 Feldmeyer D, et al., Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci. 1999 Jan;2(1):57-64
All:	6 reference(s)