Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm2Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
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mortality/aging
growth/size/body
nervous system
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• basal dendrites of CA3 cells are reduced in length and in number of branching points
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• require 30% higher stimulation currents to elicit fEPSPs of the same amplitude as wild-type and the number of failures to induce LTP is increased compared to wild-type
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• AMPA receptor currents desensitize faster and have a smaller steady-state component than wild-type
• 29-fold increase relative to wild-type in fractional calcium currents (Pf values) of AMPA receptors in CA1 pyramidal cells at a membrane potential of -60 mV, however never observe seizures
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behavior/neurological
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• show stupor from P15 onward and are hypoexcitable
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Allelic
Composition |
Gria2tm2Rsp/Gria2+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm2Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
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mortality/aging
nervous system
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• AMPA receptors have a 2-fold increase in calcium permeability in CA1 pyramidal cells, but the lack of current rectification is comparable to wild-type responses
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm2Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
Tg(Camk2a-cre)1Gsc mutation
(0 available)
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behavior/neurological
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• seizure episodes are observed, while none are seen in forebrain-specific knockouts
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nervous system
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• seizure episodes are observed, while none are seen in forebrain-specific knockouts
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• 2-fold increase in mitotic and postmitotic neurogenic cells is observed in subgranular zone (SGZ)
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• there is loss of interneurons in hippocampus
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• loss of somatostatin-positive interneurons in hilus and stratum oriens of the CA1 is observed
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• there are an increased number of glia seen in the amydala, motor cortex and somatosensory cortex
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cellular
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• 2-fold increase in mitotic and postmitotic neurogenic cells is observed in subgranular zone (SGZ)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm2Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
Tg(Camk2a-cre)1Gsc mutation
(0 available)
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behavior/neurological
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• exhibit more rapid odor learning and enhanced olfactory discrimination in a go/no-go operant conditioning task compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm2Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
Tg(Gria2*586N)238.2Rsp mutation
(0 available)
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mortality/aging
nervous system
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• exibit periodic spontaneous epileptic seizures that start at P14/15
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• develop neurosclerosis in CA3 subfield
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• calcium permeability of AMPA receptors in CA1 pyramidal neurons is increased about 4-fold relative to wild-type
• significant increase in the macroscopic AMPA receptor conductance in nucleated patches of CA1 pyramidal cells
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behavior/neurological
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• mutants are hyperexcitable
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• exibit periodic spontaneous epileptic seizures that start at P14/15
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Analysis Tools