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Rln3 Gene Detail
Summary
  • Symbol
    Rln3
  • Name
    relaxin 3
  • Synonyms
    M3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158015
    NCBI Gene: 212108
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84769696-84771608 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158015
 protein coding gene Chr8:84769558-84771629 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033850
 protein coding gene Chr8:84908908-84910988 (-)
A/J MGP_AJ_G0033833
 protein coding gene Chr8:81584617-81586696 (-)
AKR/J MGP_AKRJ_G0033759
 protein coding gene Chr8:83997266-83999340 (-)
BALB/cJ MGP_BALBcJ_G0033826
 protein coding gene Chr8:81691535-81693615 (-)
C3H/HeJ MGP_C3HHeJ_G0033536
 protein coding gene Chr8:84602535-84604614 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034346
 protein coding gene Chr8:88164685-88166756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031288
 protein coding gene Chr8:75384356-75386434 (-)
CAST/EiJ MGP_CASTEiJ_G0032866
 protein coding gene Chr8:84024454-84026531 (-)
CBA/J MGP_CBAJ_G0033512
 protein coding gene Chr8:91286262-91288341 (-)
DBA/2J MGP_DBA2J_G0033666
 protein coding gene Chr8:81221251-81223331 (-)
FVB/NJ MGP_FVBNJ_G0033613
 protein coding gene Chr8:80143067-80145138 (-)
LP/J MGP_LPJ_G0033757
 protein coding gene Chr8:85020090-85022170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033655
 protein coding gene Chr8:93784126-93786197 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034363
 protein coding gene Chr8:83968012-83970083 (-)
PWK/PhJ MGP_PWKPhJ_G0032570
 protein coding gene Chr8:80445899-80448023 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032406
 protein coding gene Chr8:82782800-82784867 (-)
WSB/EiJ MGP_WSBEiJ_G0032979
 protein coding gene Chr8:84386361-84388432 (-)



Homology
more
  • Human Ortholog
    RLN3, relaxin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RLN3, relaxin 3
  • Synonyms
    H3, insl7, RXN3, ZINS4
  • Links
    NCBI Gene ID: 117579
    neXtProt AC: NX_Q8WXF3
    UniProt: Q8WXF3

  • Chr Location
    19p13.12; chr19:14028148-14031551 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal body weight regulation, actvity levels, social investigation and behavioral despair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    42
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212108 NCBI Gene Model | MGI Sequence Detail 1913 C57BL/6J ±  kb
    transcript NM_173184 RefSeq | MGI Sequence Detail 475 Not Specified  
    polypeptide Q8CHK2 UniProt | EBI | MGI Sequence Detail 141 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 43
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:302432 Nasirova N, et al., Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus. eNeuro. 2020 Nov/Dec;7(6):ENEURO.0272-20.2020
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory