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Tfap2d Gene Detail
Summary
  • Symbol
    Tfap2d
  • Name
    transcription factor AP-2, delta
  • Synonyms
    Tcfap2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153466
    NCBI Gene: 226896
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:19173246-19236570 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 6.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153466
 protein coding gene Chr1:19173246-19244172 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015867
 protein coding gene Chr1:16704444-16773621 (+)
A/J MGP_AJ_G0015848
 protein coding gene Chr1:16501531-16557573 (+)
AKR/J MGP_AKRJ_G0015807
 protein coding gene Chr1:16527387-16588427 (+)
BALB/cJ MGP_BALBcJ_G0015804
 protein coding gene Chr1:16174768-16235491 (+)
C3H/HeJ MGP_C3HHeJ_G0015638
 protein coding gene Chr1:16575748-16635602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016258
 protein coding gene Chr1:17480103-17544314 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013979
 protein coding gene Chr1:14804072-14856755 (+)
CAST/EiJ MGP_CASTEiJ_G0015219
 protein coding gene Chr1:16661604-16721280 (+)
CBA/J MGP_CBAJ_G0015611
 protein coding gene Chr1:17871786-17935017 (+)
DBA/2J MGP_DBA2J_G0015710
 protein coding gene Chr1:16043227-16101356 (+)
FVB/NJ MGP_FVBNJ_G0015715
 protein coding gene Chr1:15836382-15903091 (+)
LP/J MGP_LPJ_G0015782
 protein coding gene Chr1:16904336-16984305 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015733
 protein coding gene Chr1:18809553-18872964 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016305
 protein coding gene Chr1:16515707-16577355 (+)
PWK/PhJ MGP_PWKPhJ_G0015003
 protein coding gene Chr1:15823340-15871353 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014784
 protein coding gene Chr1:16581637-16639256 (+)
WSB/EiJ MGP_WSBEiJ_G0015282
 protein coding gene Chr1:16443568-16505669 (+)



Homology
more
  • Human Ortholog
    TFAP2D, transcription factor AP-2 delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFAP2D, transcription factor AP-2 delta
  • Synonyms
    AP-2delta, TFAP2BL1
  • Links
    NCBI Gene ID: 83741
    neXtProt AC: NX_Q7Z6R9
    UniProt: Q7Z6R9

  • Chr Location
    6p12.3; chr6:50713526-50773033 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit loss of inferior colliculus due to apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    121
  • cDNA Data
    13
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042596 Ensembl Gene Model | MGI Sequence Detail 63325 C57BL/6J ±  kb
    transcript ENSMUST00000037294 Ensembl | MGI Sequence Detail 1761 Not Applicable  
    polypeptide ENSMUSP00000037699 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 4
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 21
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:72398 Zhao F, et al., Cloning and characterization of a novel mouse ap-2 transcription factor, ap-2delta, with unique DNA binding and transactivation properties. J Biol Chem. 2001 Nov 2;276(44):40755-60
    • Latest
      J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory