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Ezhip Gene Detail
Summary
  • Symbol
    Ezhip
  • Name
    EZH inhibitory protein
  • Synonyms
    AU022751
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147968
    NCBI Gene: 102991
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:5993273-5995473 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 2.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147968
 protein coding gene ChrX:5993272-5995474 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035502
 protein coding gene ChrX:690352-692552 (-)
A/J MGP_AJ_G0035480
 protein coding gene ChrX:671433-673633 (-)
AKR/J MGP_AKRJ_G0035413
 protein coding gene ChrX:708106-710306 (-)
BALB/cJ MGP_BALBcJ_G0035476
 protein coding gene ChrX:697032-699232 (-)
C3H/HeJ MGP_C3HHeJ_G0035184
 protein coding gene ChrX:697750-699950 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036001
 protein coding gene ChrX:719676-721876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032876
 protein coding gene ChrX:274669-276847 (-)
CAST/EiJ MGP_CASTEiJ_G0034484
 protein coding gene ChrX:623306-625507 (-)
CBA/J MGP_CBAJ_G0035154
 protein coding gene ChrX:793586-795786 (-)
DBA/2J MGP_DBA2J_G0035311
 protein coding gene ChrX:715049-717249 (-)
FVB/NJ MGP_FVBNJ_G0035258
 protein coding gene ChrX:678098-680298 (-)
LP/J MGP_LPJ_G0035389
 protein coding gene ChrX:695415-697615 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035297
 protein coding gene ChrX:738007-740207 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036018
 protein coding gene ChrX:668126-670326 (-)
PWK/PhJ MGP_PWKPhJ_G0034187
 protein coding gene ChrX:653501-655780 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034023
 protein coding gene ChrX:626027-628227 (-)
WSB/EiJ MGP_WSBEiJ_G0034607
 protein coding gene ChrX:700187-702387 (-)



Homology
more
  • Human Ortholog
    EZHIP, EZH inhibitory protein
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EZHIP, EZH inhibitory protein
  • Synonyms
    CATACOMB, CXorf67, KIP75
  • Links
    NCBI Gene ID: 340602
    neXtProt AC: NX_Q86X51
    UniProt: Q86X51

  • Chr Location
    Xp11.22; chrX:51406948-51408843 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Females homozygous for a null allele show reduced fertility, with fewer and smaller litters, smaller ovaries, and reduced primordial follicle number. Males exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    2
  • cDNA Data
    236
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073294 Ensembl Gene Model | MGI Sequence Detail 2201 C57BL/6J ±  kb
    transcript ENSMUST00000117544 Ensembl | MGI Sequence Detail 2201 Not Applicable  
    polypeptide ENSMUSP00000114041 Ensembl | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 236
      cDNA 236

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147972
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 2
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:281161 Ragazzini R, et al., EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Nat Commun. 2019 Aug 26;10(1):3858
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory