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Samd1 Gene Detail
Summary
  • Symbol
    Samd1
  • Name
    sterile alpha motif domain containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142433
    NCBI Gene: 666704
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84724145-84727044 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142433
protein coding gene Chr8:84724130-84727044 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033845
protein coding gene Chr8:84862061-84864061 (+)
A/J MGP_AJ_G0033828
protein coding gene Chr8:81537732-81540406 (+)
AKR/J MGP_AKRJ_G0033754
protein coding gene Chr8:83948019-83950780 (+)
BALB/cJ MGP_BALBcJ_G0033821
protein coding gene Chr8:81644415-81646340 (+)
C3H/HeJ MGP_C3HHeJ_G0033531
protein coding gene Chr8:84558358-84560277 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034341
protein coding gene Chr8:88111311-88113228 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031283
protein coding gene Chr8:75338090-75340887 (+)
CAST/EiJ MGP_CASTEiJ_G0032861
protein coding gene Chr8:83972703-83975350 (+)
CBA/J MGP_CBAJ_G0033507
protein coding gene Chr8:91231416-91235172 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0033608
protein coding gene Chr8:80098721-80100855 (+)
LP/J MGP_LPJ_G0033752
protein coding gene Chr8:84975166-84977091 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033650
protein coding gene Chr8:93738297-93739509 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034358
protein coding gene Chr8:83922762-83924763 (+)
PWK/PhJ MGP_PWKPhJ_G0032565
protein coding gene Chr8:80399448-80401489 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032974
protein coding gene Chr8:84337258-84339295 (+)



Homology
more
  • Human Ortholog
    SAMD1, sterile alpha motif domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMD1, sterile alpha motif domain containing 1
  • Links
    NCBI Gene ID: 90378
    neXtProt AC: NX_Q6SPF0
    UniProt: Q6SPF0

  • Chr Location
    19p13.12; chr19:14087851-14091036 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die during fetal development with failure of blood vessels to mature, exencephaly, pallor, and degradation of organs. Mice heterozygous for the allele exhibit failure to thrive and altered steroidogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 666704 NCBI Gene Model | MGI Sequence Detail 2900 C57BL/6J ±  kb
    transcript NM_001081415 RefSeq | MGI Sequence Detail 2256 C57BL/6  
    polypeptide D3YXK1 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014440 sterile alpha motif domain-containing protein 1
    • InterPro Domains
      IPR048589 SAM domain-containing protein 1-like, WH domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 49
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:333561 Campbell B, et al., Investigation of SAMD1 ablation in mice. Sci Rep. 2023 Feb 21;13(1):3000

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory