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Hscb Gene Detail
Summary
  • Symbol
    Hscb
  • Name
    HscB iron-sulfur cluster co-chaperone
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141135
    NCBI Gene: 100900
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110976936-110987643 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141135
 protein coding gene Chr5:110976936-110987673 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029894
 protein coding gene Chr5:113308935-113321976 (-)
A/J MGP_AJ_G0029860
 protein coding gene Chr5:108920129-108930638 (-)
AKR/J MGP_AKRJ_G0029798
 protein coding gene Chr5:112374721-112389371 (-)
BALB/cJ MGP_BALBcJ_G0029871
 protein coding gene Chr5:110292493-110303114 (-)
C3H/HeJ MGP_C3HHeJ_G0029591
 protein coding gene Chr5:112819432-112831691 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030324
 protein coding gene Chr5:117763509-117775587 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027553
 protein coding gene Chr5:103754621-103765199 (-)
CAST/EiJ MGP_CASTEiJ_G0028999
 protein coding gene Chr5:111680426-111693621 (-)
CBA/J MGP_CBAJ_G0029558
 protein coding gene Chr5:122192312-122205518 (-)
DBA/2J MGP_DBA2J_G0029708
 protein coding gene Chr5:108995274-109008039 (-)
FVB/NJ MGP_FVBNJ_G0029665
 protein coding gene Chr5:107667950-107679375 (-)
LP/J MGP_LPJ_G0029796
 protein coding gene Chr5:113862679-113874292 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029696
 protein coding gene Chr5:126834551-126848393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030365
 protein coding gene Chr5:111819678-111832719 (-)
PWK/PhJ MGP_PWKPhJ_G0028713
 protein coding gene Chr5:107579174-107590403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028551
 protein coding gene Chr5:109285092-109299817 (-)
WSB/EiJ MGP_WSBEiJ_G0029075
 protein coding gene Chr5:112295710-112310278 (-)



Homology
more
  • Human Ortholog
    HSCB, HscB mitochondrial iron-sulfur cluster cochaperone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSCB, HscB mitochondrial iron-sulfur cluster cochaperone
  • Synonyms
    DNAJC20, HSC20, JAC1, SIDBA5
  • Links
    NCBI Gene ID: 150274
    neXtProt AC: NX_Q8IWL3
    UniProt: Q8IWL3

  • Chr Location
    22q12.1; chr22:28742032-28757515 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSCB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043510 Ensembl Gene Model | MGI Sequence Detail 10708 C57BL/6J ±  kb
transcript ENSMUST00000056937 Ensembl | MGI Sequence Detail 804 Not Applicable  
polypeptide ENSMUSP00000062811 Ensembl | MGI Sequence Detail 234 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140838
References
more
  • Summaries
    All 35
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:290037 Crispin A, et al., Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. J Clin Invest. 2020 Jul 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory