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Sap30 Gene Detail
Summary
  • Symbol
    Sap30
  • Name
    sin3 associated polypeptide
  • Synonyms
    30kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929129
    NCBI Gene: 60406
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:57935740-57940874 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 29.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929129
 protein coding gene Chr8:57935740-57940894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033623
 protein coding gene Chr8:57211397-57216551 (-)
A/J MGP_AJ_G0033605
 protein coding gene Chr8:54796641-54801795 (-)
AKR/J MGP_AKRJ_G0033530
 protein coding gene Chr8:56426825-56431984 (-)
BALB/cJ MGP_BALBcJ_G0033602
 protein coding gene Chr8:55119735-55124889 (-)
C3H/HeJ MGP_C3HHeJ_G0033311
 protein coding gene Chr8:57081104-57086257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034118
 protein coding gene Chr8:59414979-59420132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031066
 protein coding gene Chr8:50348060-50353455 (-)
CAST/EiJ MGP_CASTEiJ_G0032637
 protein coding gene Chr8:56471042-56476197 (-)
CBA/J MGP_CBAJ_G0033290
 protein coding gene Chr8:61530684-61535994 (-)
DBA/2J MGP_DBA2J_G0033443
 protein coding gene Chr8:54605276-54610427 (-)
FVB/NJ MGP_FVBNJ_G0033384
 protein coding gene Chr8:53963463-53968614 (-)
LP/J MGP_LPJ_G0033531
 protein coding gene Chr8:57219882-57225035 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033428
 protein coding gene Chr8:63143207-63148661 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034136
 protein coding gene Chr8:56660397-56665549 (-)
PWK/PhJ MGP_PWKPhJ_G0032345
 protein coding gene Chr8:53917320-53922498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032181
 protein coding gene Chr8:55528199-55533387 (-)
WSB/EiJ MGP_WSBEiJ_G0032753
 protein coding gene Chr8:56911118-56916283 (-)



Homology
more
  • Human Ortholog
    SAP30, Sin3A associated protein 30
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAP30, Sin3A associated protein 30
  • Links
    NCBI Gene ID: 8819
    neXtProt AC: NX_O75446
    UniProt: O75446

  • Chr Location
    4q34.1; chr4:173369969-173377532 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    26
  • cDNA Data
    73
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60406 NCBI Gene Model | MGI Sequence Detail 5135 C57BL/6J ±  kb
    transcript NM_021788 RefSeq | MGI Sequence Detail 1159 ZRU/MplStud  
    polypeptide O88574 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014448 histone deacetylase complex subunit SAP30
      (term hierarchy)
    • PDB
      2LD7
    • InterPro Domains
      IPR024145 Histone deacetylase complex subunit SAP30/SAP30-like
      IPR025718 Histone deacetylase complex subunit SAP30, Sin3 binding domain
      IPR025717 Histone deacetylase complex subunit SAP30 zinc-finger
      IPR038291 SAP30, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 1
      cDNA 73
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory