Dnajb2 MGI Mouse Gene Detail - MGI:1928739 - DnaJ heat shock protein family (Hsp40) member B2

Symbol

Dnajb2
Name

DnaJ heat shock protein family (Hsp40) member B2
Synonyms

2700059H22Rik, Dnajb10, mDj8

Feature Type

protein coding gene
IDs

MGI:1928739
NCBI Gene: 56812
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:75213050-75222336 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.64 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

85 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928739	protein coding gene	Chr1:75213039-75222336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016181	protein coding gene	Chr1:75800499-75809769 (+)
A/J	MGP_AJ_G0016164	protein coding gene	Chr1:73159116-73168417 (+)
AKR/J	MGP_AKRJ_G0016121	protein coding gene	Chr1:75188284-75197564 (+)
BALB/cJ	MGP_BALBcJ_G0016119	protein coding gene	Chr1:73220046-73229137 (+)
C3H/HeJ	MGP_C3HHeJ_G0015950	protein coding gene	Chr1:75521501-75531373 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016572	protein coding gene	Chr1:78749584-78758891 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014293	protein coding gene	Chr1:68719556-68729474 (+)
CAST/EiJ	MGP_CASTEiJ_G0015534	protein coding gene	Chr1:74862062-74873114 (+)
CBA/J	MGP_CBAJ_G0015923	protein coding gene	Chr1:81309989-81319104 (+)
DBA/2J	MGP_DBA2J_G0016024	protein coding gene	Chr1:72477339-72486428 (+)
FVB/NJ	MGP_FVBNJ_G0016027	protein coding gene	Chr1:71676633-71687429 (+)
LP/J	MGP_LPJ_G0016096	protein coding gene	Chr1:76924756-76934041 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016047	protein coding gene	Chr1:84667879-84677134 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016619	protein coding gene	Chr1:75259271-75268556 (+)
PWK/PhJ	MGP_PWKPhJ_G0015321	protein coding gene	Chr1:71948813-71958209 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015099	protein coding gene	Chr1:74621775-74630978 (+)
WSB/EiJ	MGP_WSBEiJ_G0015596	protein coding gene	Chr1:75071169-75080444 (+)

Human Ortholog

DNAJB2, DnaJ heat shock protein family (Hsp40) member B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB2, DnaJ heat shock protein family (Hsp40) member B2
Synonyms

CMT2T, DSMA5, HMNR5, HSJ1, HSJ-1, HSPF3
Links

HGNC:5228

NCBI Gene ID: 3300

neXtProt AC: NX_P25686

UniProt: P25686
Chr Location

2q35; chr2:219279342-219286898 (+) GRCh38

MGI Vertebrate Homology

Dnajb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJB2
Gene Tree

Dnajb2

Diseases

1 with human DNAJB2 associations

				Human Disease	Mouse Models
				autosomal recessive distal hereditary motor neuronopathy 5 IDs autosomal recessive distal hereditary motor neuronopathy 5 DOID:0111214 OMIM:614881 ORDO:314485

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Dnajb2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

less

All GO Annotations

58
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

4
cDNA Data

81
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb2

ZFIN dnajb2

less

All Sequences

82
RefSeq

24
UniProt

4
CCDS

CCDS15068.1, CCDS35624.1, CCDS78622.1

Ensembl

ENSMUSG00000026203 (Evidence)
NCBI Gene

56812

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026203	Ensembl Gene Model \| MGI Sequence Detail	9287	C57BL/6J	± kb
transcript	ENSMUST00000188931	Ensembl \| MGI Sequence Detail	3066	Not Applicable
polypeptide	ENSMUSP00000140566	Ensembl \| MGI Sequence Detail	324	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000029422 DnaJ homolog subfamily B member 2

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR043183 DnaJ homolog subfamily B member 2/6-like

IPR003903 Ubiquitin interacting motif

less

All nucleic 81

cDNA 81

Microarray probesets 4

less

MGI:1923843

Summaries

All 53

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 25
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Dnajb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7500	Chr1:75213044-75213073 (+)	9 bp
Tssr7501	Chr1:75213083-75213113 (+)	48 bp
Tssr7502	Chr1:75213115-75213136 (+)	76 bp
Tssr7503	Chr1:75213142-75213165 (+)	104 bp
Tssr7504	Chr1:75213171-75213192 (+)	132 bp
Tssr7505	Chr1:75213221-75213232 (+)	177 bp
Tssr7506	Chr1:75213260-75213271 (+)	216 bp
Tssr7507	Chr1:75213303-75213309 (+)	256 bp
Tssr7508	Chr1:75213397-75213405 (+)	351 bp
Tssr7509	Chr1:75213409-75213447 (+)	378 bp
Tssr7510	Chr1:75213608-75213616 (+)	562 bp
Tssr7511	Chr1:75213617-75213635 (+)	576 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23