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Mettl15 Gene Detail
Summary
  • Symbol
    Mettl15
  • Name
    methyltransferase like 15
  • Synonyms
    0610027B03Rik, Mett5d1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924144
    NCBI Gene: 76894
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:108922642-109111093 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 56.52 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924144
 protein coding gene Chr2:108922642-109111100 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026238
 protein coding gene Chr2:111412464-111608375 (-)
A/J MGP_AJ_G0026199
 protein coding gene Chr2:106735132-106926444 (-)
AKR/J MGP_AKRJ_G0026179
 protein coding gene Chr2:109730014-109945564 (-)
BALB/cJ MGP_BALBcJ_G0026208
 protein coding gene Chr2:107015568-107197103 (-)
C3H/HeJ MGP_C3HHeJ_G0025958
 protein coding gene Chr2:110039302-110229521 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026659
 protein coding gene Chr2:115033054-115250233 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024045
 protein coding gene Chr2:102352679-102530985 (-)
CAST/EiJ MGP_CASTEiJ_G0025423
 protein coding gene Chr2:110515767-110720735 (-)
CBA/J MGP_CBAJ_G0025936
 protein coding gene Chr2:119023979-119246299 (-)
DBA/2J MGP_DBA2J_G0026074
 protein coding gene Chr2:106257935-106437842 (-)
FVB/NJ MGP_FVBNJ_G0026037
 protein coding gene Chr2:105186148-105364366 (-)
LP/J MGP_LPJ_G0026177
 protein coding gene Chr2:111570784-111782804 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026061
 protein coding gene Chr2:123102097-123352046 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026713
 protein coding gene Chr2:109897258-110084797 (-)
PWK/PhJ MGP_PWKPhJ_G0025158
 protein coding gene Chr2:105895338-106074753 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024958
 protein coding gene Chr2:109113214-109315276 (-)
WSB/EiJ MGP_WSBEiJ_G0025490
 protein coding gene Chr2:110643622-110847738 (-)



Homology
more
  • Human Ortholog
    METTL15, methyltransferase 15, mitochondrial 12S rRNA N4-cytidine
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL15, methyltransferase 15, mitochondrial 12S rRNA N4-cytidine
  • Synonyms
    METT5D1
  • Links
    NCBI Gene ID: 196074
    neXtProt AC: NX_A6NJ78
    UniProt: A6NJ78

  • Chr Location
    11p14.1; chr11:28108248-28532475 (+)  GRCh38
  • Human Ortholog
    METTL15P1, methyltransferase like 15 pseudogene 1
  • Synonyms
    METT5D2
  • Links
    NCBI Gene ID: 100130758
    UniProt: P0C7V9

  • Chr Location
    3q25.31; chr3:156711403-156715029 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired learning and hypoglycemia after exercise.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057234 Ensembl Gene Model | MGI Sequence Detail 188452 C57BL/6J ±  kb
    transcript ENSMUST00000081631 Ensembl | MGI Sequence Detail 1894 Not Applicable  
    polypeptide ENSMUSP00000080337 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031553 12S rRNA N4-methylcytidine (m4C) methyltransferase
      (term hierarchy)
    • PDB
      7PNV
    • EC
      2.1.1.-
    • InterPro Domains
      IPR002903 Ribosomal RNA small subunit methyltransferase H
      IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138875, MGI:2141137
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:325995 Averina OA, et al., Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice. Int J Mol Sci. 2022 May 27;23(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory