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Atg16l2 Gene Detail
Summary
  • Symbol
    Atg16l2
  • Name
    autophagy related 16 like 2
  • Synonyms
    2410118P20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920933
    NCBI Gene: 73683
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100935521-100951474 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920933
 protein coding gene Chr7:100912241-100951474 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032582
 protein coding gene Chr7:104248296-104263984 (-)
A/J MGP_AJ_G0032556
 protein coding gene Chr7:101587791-101600479 (-)
AKR/J MGP_AKRJ_G0032492
 protein coding gene Chr7:104005746-104021855 (-)
BALB/cJ MGP_BALBcJ_G0032567
 protein coding gene Chr7:101276847-101289884 (-)
C3H/HeJ MGP_C3HHeJ_G0032282
 protein coding gene Chr7:104408692-104422978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033065
 protein coding gene Chr7:108182806-108198356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030059
 protein coding gene Chr7:103963483-103976337 (-)
CAST/EiJ MGP_CASTEiJ_G0031609
 protein coding gene Chr7:95956984-95972848 (-)
CBA/J MGP_CBAJ_G0032249
 protein coding gene Chr7:111923973-111939946 (-)
DBA/2J MGP_DBA2J_G0032400
 protein coding gene Chr7:99941112-99954131 (-)
FVB/NJ MGP_FVBNJ_G0032357
 protein coding gene Chr7:99710818-99723599 (-)
LP/J MGP_LPJ_G0032490
 protein coding gene Chr7:105572511-105585410 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032390
 protein coding gene Chr7:113290456-113304488 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033087
 protein coding gene Chr7:103289003-103303330 (-)
PWK/PhJ MGP_PWKPhJ_G0031327
 protein coding gene Chr7:93061641-93075616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031170
 protein coding gene Chr7:90587852-90601457 (-)
WSB/EiJ MGP_WSBEiJ_G0031726
 protein coding gene Chr7:103999226-104013904 (-)



Homology
more
  • Human Ortholog
    ATG16L2, autophagy related 16 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG16L2, autophagy related 16 like 2
  • Synonyms
    ATG16B, WDR80
  • Links
    NCBI Gene ID: 89849
    neXtProt AC: NX_Q8NAA4
    UniProt: Q8NAA4

  • Chr Location
    11q13.4; chr11:72814406-72843740 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Atg16l2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    37 strains or lines available
Mice homozygous for an ENU-induced allele exhibit lymphopenia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    32
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73683 NCBI Gene Model | MGI Sequence Detail 15954 C57BL/6J ±  kb
transcript NR_152152 RefSeq | MGI Sequence Detail 2497 C57BL/6  
polypeptide Q6KAU8 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 2
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:342794 Wang D, et al., ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. Eur J Immunol. 2022 Apr 15;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory