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Aida Gene Detail
Summary
  • Symbol
    Aida
  • Name
    axin interactor, dorsalization associated
  • Synonyms
    2610208M17Rik, MGC:6869
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919737
    NCBI Gene: 108909
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:183078604-183105356 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919737
 protein coding gene Chr1:183078134-183106331 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016902
 protein coding gene Chr1:189943056-189971760 (+)
A/J MGP_AJ_G0016881
 protein coding gene Chr1:182183720-182215768 (+)
AKR/J MGP_AKRJ_G0016846
 protein coding gene Chr1:187602950-187638152 (+)
BALB/cJ MGP_BALBcJ_G0016839
 protein coding gene Chr1:182827265-182855991 (+)
C3H/HeJ MGP_C3HHeJ_G0016663
 protein coding gene Chr1:188399286-188431428 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017302
 protein coding gene Chr1:196040285-196073366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015009
 protein coding gene Chr1:173240971-173269099 (+)
CAST/EiJ MGP_CASTEiJ_G0016246
 protein coding gene Chr1:187790675-187819970 (+)
CBA/J MGP_CBAJ_G0016637
 protein coding gene Chr1:203346446-203379146 (+)
DBA/2J MGP_DBA2J_G0016743
 protein coding gene Chr1:180965786-180997524 (+)
FVB/NJ MGP_FVBNJ_G0016739
 protein coding gene Chr1:179099495-179127924 (+)
LP/J MGP_LPJ_G0016818
 protein coding gene Chr1:191131237-191162462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016771
 protein coding gene Chr1:210291987-210319981 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017339
 protein coding gene Chr1:187427321-187459389 (+)
PWK/PhJ MGP_PWKPhJ_G0016033
 protein coding gene Chr1:180166667-180198467 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015809
 protein coding gene Chr1:186390849-186421260 (+)
WSB/EiJ MGP_WSBEiJ_G0016308
 protein coding gene Chr1:187605976-187634879 (+)



Homology
more
  • Human Ortholog
    AIDA, axin interactor, dorsalization associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AIDA, axin interactor, dorsalization associated
  • Synonyms
    C1orf80
  • Links
    NCBI Gene ID: 64853
    neXtProt AC: NX_Q96BJ3
    UniProt: Q96BJ3

  • Chr Location
    1q41; chr1:222668013-222713210 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to increased lipid absorption and fat deposits, resulting in severe obesity, hypertriglyceridemia, hyperglycemia and hyperinsulinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    94
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108909 NCBI Gene Model | MGI Sequence Detail 26753 C57BL/6J ±  kb
    transcript NM_181732 RefSeq | MGI Sequence Detail 3293 ZRU/MplStud  
    polypeptide Q8C4Q6 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003865 Axin interactor, dorsalization-associated protein
      (term hierarchy)
    • PDB
      1UG7, 2QZ5
    • InterPro Domains
      IPR025939 Axin interactor dorsalization-associated protein, C-terminal
      IPR023421 Axin interactor, dorsalization-associated protein, N-terminal
      IPR036818 Axin interactor, dorsalization-associated protein, N-terminal domain superfamily
      IPR035892 C2 domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 94

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2384293
    References
    more
    • Summaries
      All 27
      Gene Ontology 3
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:305261 Shi M, et al., AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1. Nat Cell Biol. 2021 Mar;23(3):268-277
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory